Thyromimetics

A compound having the structure of Formula (I):

• or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein:
• X1 is lower alkyl, lower haloalkyl, or halo;
• X2 is lower alkyl, lower haloalkyl, or halo;
• R1 is —NR1aR1b or —OR1c;
• R1a and R1b are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, —ORa, —NRaRb, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or R1a and R1b taken together with the nitrogen atom to which they are attached form heterocycle;
• R1c is H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl;
• Q is a bond;
• A is aryl or heteroaryl;
• each R2 is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, —ORa, —NRaRb, —C(O)Ra, —C(O)ORa, —C(O)NRaRb, —NRaC(O)Rb, —S(O)2Ra, or —S(O)2ORa;
• n is 1-5;
• and
• Ra and Rb are each, independently, H, lower alkyl, or lower haloalkyl;
• wherein R1a, R1b, R1c, R2, Ra, and Rb are each, independently, optionally substituted with one or more halo, cyano, —OR′, —NR′R″, —S(O)2R′ or —S(O)2OR′, wherein R′ and R″ are each, independently, H, lower alkyl, or lower haloalkyl.