Methods, systems, and compositions for maintaining functioning drainage blebs associated with minimally invasive micro sclerostomy
AssigneeRadiance Therapeutics, Inc.
InventorLaurence J. Marsteller
Life of this patent
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Abstract
Methods, systems, and compositions for maintaining functioning drainage blebs to reduce intraocular pressure (IOP) of an eye being treated for glaucoma. The methods, systems, and compositions feature the combination of a minimally invasive micro sclerostomy (MIMS) procedure and the application of beta radiation to a target area. The beta radiation can function to inhibit or reduce the inflammation and/or fibrogenesis that typically occurs after a MIMS procedure and leads to hole and/or bleb failure. By reducing inflammation and/or fibrogenesis, the MIMS holes and/or blebs can remain functioning appropriately.
Claims26
A method of treating glaucoma or reducing intraocular pressure (IOP) in an eye of a patient, said method comprising:
- performing minimally invasive micro sclerostomy in the eye of the patient to form a drainage channel from an anterior chamber to allow aqueous humor to drain into a bleb in a subconjunctival space or space between a conjunctiva and Tenon's capsule;
- and
- b. applying a therapeutic dose of beta radiation from a radioisotope that emits beta radiation to a target area of the eye, wherein the target area is tissue surrounding a rim of the drainage channel;
- wherein the therapeutic dose of beta radiation at any point of the target area is within 10% of a dose of beta radiation at any other point on the target;
- wherein the method is effective for reducing an Intraocular Pressure (IOP) of the eye or treating glaucoma.
A method of maintaining a functioning drainage bleb or drainage channel in an eye of a patient being treated with minimally invasive micro sclerostomy, the eye having a drainage channel from an anterior chamber to allow aqueous humor to drain into a bleb in a subconjunctival space or space between a conjunctiva and Tenon's capsule, said method comprising:
- applying a therapeutic dose of beta radiation from a radioisotope that emits beta radiation to a target area of the eye, wherein the target area is tissue surrounding a rim of the drainage channel;
- wherein the therapeutic dose of beta radiation at any point of the target area is within 10% of a dose of beta radiation at any other point on the target;
- wherein the therapeutic dose of beta radiation is effective to maintain drainage of the bleb or drainage channel.
A method of inhibiting or reducing fibrogenesis and inflammation in a bleb of an eye or a drainage channel of an eye being treating with minimally invasive micro sclerostomy, the eye having a drainage channel from an anterior chamber to allow aqueous humor to drain into a bleb in a subconjunctival space or space between a conjunctiva and Tenon's capsule, said method comprising:
- applying a therapeutic dose of beta radiation from a radioisotope that emits beta radiation to a target area of the eye, wherein the target area is tissue surrounding a rim of the drainage channel;
- wherein the therapeutic dose of beta radiation at any point of the target area is within 10% of a dose of beta radiation at any other point on the target;
- wherein the therapeutic dose of beta radiation causes inhibition or reduction of a fibrotic process and inflammation that otherwise leads to bleb failure or drainage channel failure.
Dependencies are inferred from the claim text.