Self assembling molecules for targeted drug delivery
AssigneeThe General Hospital Corporation
InventorsDavid R. Elmaleh, Kazue Takahashi
Life of this patent
Estimating the term…
Abstract
Described herein are self-assembling protein molecules for delivering a payload, for example, a toxic anti-cancer agent, a cancer immunotherapy, a toxic anti-cancer agent and a cancer immunotherapy, or an imaging agent, to specific tissues. Examples of self-assembled proteins include clathrin and derivatives of clathrin.
Claims8
A composition comprising a clathrin light chain covalently conjugated to an anti-cancer agent, wherein the anti-cancer agent is selected from paclitaxel, gemcitabine, azonafide, colcemid, colchicine, vinblastine and vincristine, wherein the clathrin light chain comprises SEQ ID NO:
- 4, wherein the composition does not comprise a clathrin heavy chain, and wherein the composition does not comprise any targeting agent.
Dependencies are inferred from the claim text.