Methods and compositions for management of gastrointestinal disorders
AssigneeBoard of Regents, The University of Texas System
InventorWilliam T. Phillips
Life of this patent
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Abstract
Described herein are methods of management of functional dyspepsia in a patient by administering an amylin analogue or a CCK composition to the patient. Methods of diagnosing such patient include a standard gastric-emptying assessment using a standardized solid meal along with measurements of blood glucose levels. Another method of diagnosing such patient includes a gastric-emptying scintigraphy assessment with labeled carbohydrates or other assessments to diagnose rapid carbohydrate gastric emptying.
Claims6
A method of treatment of functional dyspepsia in a subject, the method including the steps of:
- classifying the subject as having normal or delayed gastric emptying based on a standard gastric-emptying scintigraphy assessment using a standardized solid meal;
- classifying the subject as having elevated glycemic excursion due to rapid carbohydrate gastric emptying based on one or more measurements of blood glucose levels of the subject during the standard gastric-emptying scintigraphy assessment;
- and
- administering an amylin analogue to the subject upon being classified as having normal or delayed solid gastric emptying and elevated glycemic excursion.
A method of treatment of functional dyspepsia in a subject, the method including the steps of:
- classifying the subject as having normal or delayed gastric emptying based on a standard gastric-emptying scintigraphy assessment using a standardized solid meal, wherein the subject has emptied less than 90% of a standardized solid meal at 4 hours, less than 10% of the standardized solid meal at 1-2 hours, 30% or less of the standardized solid meal at 30 minutes, and/or 70% or less of the standardized solid mean at 1 hour;
- classifying the subject as having elevated glycemic excursion due to rapid carbohydrate gastric emptying based on one or more measurements of blood glucose levels of the subject during the standard gastric-emptying scintigraphy assessment;
- and
- administering an amylin analogue to the subject upon being classified as having normal or delayed solid gastric emptying and elevated glycemic excursion.
A method of treatment of functional dyspepsia in a subject, the method including the steps of:
- classifying the subject as having normal or delayed gastric emptying based on a standard gastric-emptying scintigraphy assessment using a standardized solid meal;
- classifying the subject as having elevated glycemic excursion due to rapid carbohydrate gastric emptying based on one or more measurements of blood glucose levels of the subject during the standard gastric-emptying scintigraphy assessment, wherein the glycemic excursion above baseline was greater than 75 mg/dL at 30 minutes or greater than 85 mg/dL at 1 hour;
- and
- administering an amylin analogue to the subject upon being classified as having normal or delayed solid gastric emptying and elevated glycemic excursion.
Dependencies are inferred from the claim text.