PSMA-targeting compounds and uses thereof

A compound having the structure:

• wherein:
• Z is tetrazole or CO2Q;
• each Q is independently selected from hydrogen or a protecting group;
• a is 1, 2, 3, or 4;
• R is each independently H or C1-C4 alkyl;
• Ch is a metal chelating moiety optionally including a chelated metal, wherein Ch optionally includes any additional atoms or linkers necessary to attach the metal chelating moiety to the rest of the compound;
• W is —NRC(O)—, —NRC(O)NR—, NRC(S)NR—, —NRC(O)O—, —OC(O)NR—, —OC(O)—, —C(O)NR—, or —C(O)O—;
• Y is —C(O)—, —NRC(O)—, —NRC(S)—, —OC(O);
• V is —C(O)—, —NRC(O)—, —NRC(S)—, or —OC(O)—;
• m is 1, 2, 3, 4, 5, or 6;
• n is 1, 2, 3, 4, 5 or 6;
• p is 1, 2, or 3, and when p is 2 or 3, each R1 may be the same or different;
• R1 is H, C1-C6 alkyl, C2-C12 aryl, or C4-C16 alkylaryl;
• R2 and R3 are independently H, CO2H, or CO2R4, wherein R4 is a C1-C6 alkyl, C2-C12 aryl, or C4-C16 alkylaryl, wherein when one of R2 and R3 is CO2H or CO2R4, the other is H, and when p is 0, one of R2 and R3 is CO2R4, and the other is H.