1,4-disubstituted imidazole derivative

A process of preparing a compound of formula (1-7):

• or a pharmaceutically acceptable salt thereof, wherein ring Q1 is optionally-substituted C6-10 aryl, optionally-substituted C3-10 cycloalkyl, or optionally-substituted 5- to 10-membered heteroaryl;
• R1 and R2 are each independently hydrogen, halogen, or C1-6 alkyl, wherein said C1-6 alkyl is optionally substituted with 1 to 3 halogen atoms;
• W1 is optionally-substituted C1-4 alkylene;
• ring Q2 is 5- to 10-membered heteroaryl;
• W3 is optionally-substituted C1-4 alkylene, optionally-substituted C3-4 alkenylene, or optionally-substituted C3-4 alkynylene;
• n is 1, 2, 3, 4, or 5;
• each R4 is independently hydrogen, halogen, optionally-substituted C1-6 alkyl, optionally-substituted C1-6 alkoxy, optionally-substituted C3-10 cycloalkyl, optionally-substituted C2-6 alkenyl, optionally-substituted C2-6 alkynyl, cyano, or optionally-substituted amino;
• or, any R4 and W3 attached to adjacent carbon atoms on ring Q2, together with the carbon atoms to which they are attached, form a 5- to 8-membered cycloalkane ring;
• and
• R5 is
• (1) hydroxy,
• (2) C1-6 alkoxy optionally substituted with 1 to 3 substituents each independently halogen, hydroxy, C1-6 alkoxy, or C6-10 aryl, wherein said C6-10 aryl is optionally substituted with 1 to 4 substituents each independently halogen, C1-6 alkyl, or C1-6 alkoxy,
• (3) amino, which is optionally substituted with 1 or 2 C1-6 alkyl, or
• (4) C1-6 alkyl-carbonylamino, wherein the alkyl moiety thereof is optionally substituted with 1 to 3 halogen;
• the process comprising:
• reacting compound (1-6):
• with compound (1-2):
• in an inert solvent in the presence of a condensation agent, wherein the compound (1-2) is prepared according to a process comprising hydrolyzing compound (1-1):
• wherein R101 is C1-6 alkyl.