Device, system, and formulation for oral delivery of functionalized particles

A device comprising:

• a capsule sized to pass through a lumen of a gastrointestinal tract;
• an enteric coating surrounding at least a portion of the capsule, the enteric coating configured to protect the capsule from stomach acid while allowing for degradation of the capsule in a target portion of the gastrointestinal tract;
• a plurality of tissue penetrating members arranged within the capsule and configured to puncture a wall of the lumen of the target portion of the gastrointestinal tract, the tissue penetrating members comprising at least one type of functionalized particles;
• and
• an actuator having a first configuration and a second configuration, wherein the actuator is configured to retain the plurality of tissue penetrating members within the capsule in the first configuration, wherein the actuator is configured to advance the at least one type of functionalized particles into or across a wall of the lumen of the target portion of the gastrointestinal tract via the plurality of tissue penetrating members by the actuator transitioning from the first configuration to the second configuration, wherein the actuator comprises an expandable polymer configured to expand after the capsule arrives at the target portion of the gastrointestinal tract,
• wherein the actuator is not a balloon;
• wherein the expandable polymer is a pH-triggered expandable polymer,
• wherein the plurality of tissue penetrating members is around the expandable polymer, and
• wherein the expandable polymer is configured to advance the plurality of tissue penetrating members.