Vaccines against coronavirus and methods of use
AssigneesInovio Pharmaceuticals, Inc., The Wistar Institute of Anatomy and Biology
InventorsJian Yan, Kate Broderick, David Weiner, Kar Muthumani, Ami Patel
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Abstract
Disclosed herein are nucleic acid molecules encoding a SARS-CoV-2 spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection in a subject.
Claims21
A nucleic acid molecule encoding a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) spike antigen, the nucleic acid molecule comprising:
- a nucleic acid sequence having at least 99% identity to the nucleic acid sequence set forth from nucleotide 55 to nucleotide 3837 of SEQ ID NO:
- 2;
- the nucleic acid sequence from nucleotide 55 to nucleotide 3837 of SEQ ID NO:
- 2;
- or
- the nucleic acid sequence of SEQ ID NO:
- 2.
An expression vector comprising a nucleic acid molecule encoding a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) spike antigen, the nucleic acid molecule comprising:
- a nucleic acid sequence having at least 99% identity to the nucleic acid sequence set forth from nucleotide 55 to nucleotide 3837 of SEQ ID NO:
- 2;
- the nucleic acid sequence from nucleotide 55 to nucleotide 3837 of SEQ ID NO:
- 2;
- or
- the nucleic acid sequence of SEQ ID NO:
- 2.
An immunogenic composition comprising an effective amount of an expression vector and a pharmaceutically acceptable excipient, wherein the expression vector comprises a nucleic acid molecule encoding a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) spike antigen, the nucleic acid molecule comprising:
- a nucleic acid sequence having at least 99% identity to the nucleic acid sequence set forth from nucleotide 55 to nucleotide 3837 of SEQ ID NO:
- 2;
- the nucleic acid sequence from nucleotide 55 to nucleotide 3837 of SEQ ID NO:
- 2;
- or
- the nucleic acid sequence of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.