Engineered cells with decreased gene expression resulting in increased viral production
AssigneeUniversity of Georgia Research Foundation, Inc.
InventorRalph A Tripp
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Abstract
Disclosed are compositions and methods for increasing virus production. In particular, disclosed herein are cell or cell line comprises reduced expression of one or more cellular genes selected from the group comprising COQ9, FGF2, NAT9, NDUFA9, NEU2, PLA2G1B, PYCR1, RAD51AP1, STRADA, SVOPL, and/or ZFYVE9 for use in increasing viral production.
Claims5
An isolated cell or cell line comprising decreased expression of PLA2G1B and one or more of BTN2A1, CNTD2, COQ9, EMX2, EP300, FGF2, GCGR, NAT9, NDUFA9, NEU2, PYCR1, RAD51AP1, SEC61G, STRADA, SVOPL, ZFYVE9, and ZNF205.
An isolated cell or cell line comprising decreased expression of PLA2G1 B and one or more of BTN2A1, CNTD2, ZNF205, GCGR, and EP300;
- and decreased expression of one or more of COQ9, NAT9, NDUFA9, NEU2, RAD51AP1, and SVOPL.
Dependencies are inferred from the claim text.