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US 11,655,299 B2Granted
Antibodies against human and canine IL-13RA2
AssigneeWake Forest University Health Sciences
InventorsWaldemar Debinski, Denise Mazess Herpai
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Abstract
Provided herein are monoclonal antibodies that specifically bind IL-13RA2 with cross-reactivity in humans and canines. Also provided are methods of use of the antibodies in the treatment and monitoring of cancers.
Claims20
A method of detecting a cancer in a subject in need thereof, said method comprising:
- administering to said subject an antibody that specifically binds an epitope within amino acids spanning the extracellular portion of human IL-13RA2, wherein said antibody is coupled to a detectable group, in an amount effective to detect said antibody;
- and
- detecting said detectable group, to thereby detect the cancer in the subject,
- wherein said epitope is within amino acids of SEQ ID NO:
- 1 (Peptide 1);
- SEQ ID NO:
- 2 (Peptide 2);
- or SEQ ID NO:
- 3 (Peptide 3),
- wherein said antibody comprises a variable light chain amino acid sequence of SEQ ID NO:8 or at least 95% identity thereto, and a variable heavy chain amino acid sequence of SEQ ID NO:10 or at least 95% identity thereto, and
- wherein said antibody specifically binds to both human and canine IL-13RA2.
8 more elements
Dependencies are inferred from the claim text.