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US 11,655,282 B2Granted
Chimeric engulfment receptor molecules
AssigneeCero Therapeutics, Inc.
InventorDaniel Mark Corey
Life of this patent
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Abstract
The present disclosure relates to chimeric engulfment receptor molecules, host cells modified to include the phagocytic engulfment molecules, and methods of making and using such receptor molecules and modified cells.
Claims12
A chimeric engulfment receptor (CER) comprising a single chain chimeric protein, the single chain chimeric protein comprising:
- an extracellular domain comprising a Tim4 binding domain that binds to phosphatidylserine (PtdSer);
- an engulfment signaling domain, wherein the engulfment signaling domain comprises an ItgB5, MERTK, Tyro3, Ax1, BAI1, ELMO, MRC1, PI3K, Traf6, Syk, MyD88, Zap70, FcγR1, FcγR2A, FcγR2B2, FcγR2C, FcγR3A, FcεR1, FcαR1, BAFF-R, DAP12, NFAM1, or CD79b engulfment signaling domain;
- and
- a transmembrane domain positioned between and connecting the extracellular domain and the engulfment signaling domain.
1 more element
Dependencies are inferred from the claim text.