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US 11,654,189 B2Granted
Compositions and methods for enhancing the stability of transgenes in poxviruses
AssigneeBavarian Nordic A/S
InventorsMarkus Kalla, Ryan Rountree, Ulrike Dirmeier
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Abstract
Provided herein are recombinant poxviruses that are stable through successive passaging of the recombinant poxviruses. More particularly, the recombinant poxviruses comprise one or more modified nucleic acids encoding MUC1, CEA, and/or TRICOM antigens, wherein the recombinant poxviruses are stable through successive passaging. Also, provided herein are compositions and method related thereto.
Claims21
A method for generating a recombinant poxvirus that is stable through successive passaging of the recombinant poxvirus, the method comprising:
- providing a first nucleic acid encoding a MUC1 protein having at least two Variable N-Terminal Repeat (VNTR) domains, wherein (a) the arrangement of the at least two VNTR domains are shuffled, and (b) the at least two VNTR domains are codon optimized,
- wherein the recombinant poxvirus is stable through successive passaging.
Dependencies are inferred from the claim text.