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US 11,654,160 B2Granted
Processes for making and using a mesenchymal stem cell derived secretome
AssigneeCombangio, Inc.
InventorSpencer Alford
Life of this patent
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Abstract
The present application provides methods and processes for making and using a mesenchymal stem cell secretome, as well as methods for treating ocular conditions and/disorders with the mesenchymal stem cell secretome described herein.
Claims22
A method of treatment for an ocular condition in a subject in need thereof comprising administering to the subject a bone marrow-derived mesenchymal stem cell (MSC) secretome composition, wherein the MSC secretome composition comprises:
- HGF;
- Pentraxin-3 (TSG-14);
- VEGF;
- TIMP-1;
- Serpin E1;
- <5 ng/mL IL-8 and a tonicity modifying agent, and wherein the ocular condition is selected from the group consisting of:
- ocular wound, ocular scarring, ocular neovascularization, increased intraocular pressure, dry eye disease, damaged corneal surface, damaged ocular nerve tissue, retina condition, persistent corneal epithelial defects (PCED), Graft v. Host Disease (GvHD), and Stevens-Johnson Syndrome.
4 more elements
Dependencies are inferred from the claim text.