Nutritional formulations including human milk oligosaccharides and antioxidants and uses thereof

A nutritional composition comprising a human milk oligosaccharide selected from the group consisting of 6′-sialyllactose, 3′-sialyllactose, 2′-fucosyllactose, 3-fucosyllactose, lacto-N-tetraose, lacto-N-neotetraose, lacto-N-fucopentaose, and combinations thereof, wherein, when the composition is in the form of a liquid, the composition comprises:

• a polyunsaturated fatty acid, wherein the polyunsaturated fatty acid comprises docosahexaenoic acid and arachidonic acid in a ratio of docosahexaenoic acid to arachidonic acid of from 1:4 to 1:2, from about 0.5 μg/mL to about 5 μg/mL of a carotenoid, wherein the carotenoid consists of at most two of lutein, lycopene, and beta-carotene, wherein the human milk oligosaccharide is derived from a source selected from human, bovine, ovine, porcine, caprine, or combinations thereof;
• from about 72 mg/L to about 200 mg/L of a nucleotide component, wherein the nucleotide comprises at least one salt, and wherein the nutritional composition is shelf stable from about 3 months to about 24 months.

A method of stimulating immune activity against a respiratory virus in an infant, toddler, or child in need thereof, the method comprising administering to the infant, child or toddler a nutritional composition comprising a human milk oligosaccharide, a polyunsaturated fatty acid comprising docosahexaenoic acid and arachidonic acid, wherein the polyunsaturated fatty acid comprises 0.105 mg/mL to 0.38 mg/mL of a combination of docosahexaenoic acid and arachidonic acid, wherein the polyunsaturated fatty acid comprises a ratio of docosahexaenoic acid to arachidonic acid of from 1:4 to 1:2, from about 72 mg/L to about 200 mg/L of a nucleotide component, and from about 0.5 μg/mL to about 5 μg/mL of a carotenoid.

A nutritional composition comprising a human milk oligosaccharide selected from the group consisting of 6′-sialyllactose, 3′-sialyllactose, 2′-fucosyllactose, 3-fucosyllactose, lacto-N-tetraose, lacto-N-neotetraose, lacto-N-fucopentaose, and combinations thereof, wherein, when the composition is in the form of a liquid, the composition comprises:

• a polyunsaturated fatty acid comprising docosahexaenoic acid and from 0.080 mg/mL to 0.250 mg/mL of arachidonic acid, wherein the polyunsaturated fatty acid comprises a ratio of docosahexaenoic acid to arachidonic acid of from 1:4 to 1:2, from about 0.5 μg/mL to about 5 μg/mL of a carotenoid, wherein the carotenoid consists of at most two of lutein, lycopene, and beta-carotene, from about 72 mg/L to about 200 mg/L of a nucleotide component, wherein the nucleotide comprises at least one salt, and wherein the nutritional composition is shelf stable from about 3 months to about 24 months.