Functional, segregated, charged telodendrimers and nanocarriers and methods of making and using same
AssigneeThe Research Foundation for The State University of New York
InventorsJuntao Luo, Xu Wang, Changying Shi
Life of this patent
Estimating the term…
Abstract
Provided are multiply functional charged telodendrimers. The telodendrimers can be used for protein encapsulation and delivery. The charged telodendrimers may have one or more crosslinking groups (e.g., boronic acid/catechol reversible crosslinking groups). The telodendrimers can aggregate to form nanoparticles. Cargo such as combinations of proteins and other materials may be sequestered in the core of the nanoparticles via non-covalent or covalent interactions with the telodendrimers. Such nanoparticles may be used in protein delivery applications.
Claims18
A compound of formula (I):
- wherein
- PEG is optionally present and is a polyethylene glycol moiety, wherein PEG has a molecular weight of 44 Da to 100 kDa;
- X is optionally present and is a branched monomer unit;
- each L1 is independently optional and is a linker group;
- each L2 is independently optional and is a linker group;
- each L3 is independently optional and is a linker group;
- each L4 is independently optional and is a linker group;
- D1 is optional and is a dendritic polymer moiety having one or more branched monomer units (X), and a plurality of end groups;
- D2 is a dendritic polymer having one or more branched monomer units (X), and a plurality of end groups;
- R1 is optional and is an end group of the dendritic polymer and is independently at each occurrence in the compound selected from the group consisting of crosslinkable groups;
- R2 is an end group of the dendritic polymer and is independently at each occurrence in the compound selected from the group consisting of positively or negatively charged groups and neutral groups, where at least one positively or negatively charged groups are present in R2;
- subscript x is an integer from 1 to 64, wherein subscript x is equal to the number of end groups on the dendritic polymer;
- subscript y is an integer from 1 to 64, wherein subscript y is equal to the number of end groups on the dendritic polymer;
- subscript p is an integer from 0 to 32;
- and
- subscript m is an integer from 0 to 32;
- wherein at least one of the R1 groups is present as reversible crosslinking groups;
- and wherein L1 and L3 are not the same.
Dependencies are inferred from the claim text.