Indazoles as hematopoietic progenitor kinase 1 (HPK1) inhibitors and methods using same

A compound of Formula (I):

• or a pharmaceutically acceptable salt, hydrate, or solvate, thereof, wherein:
• X is O or S;
• L is a bond, —O—, —S—, or —NR6—;
• R1 is alkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl, wherein R1 is optionally substituted with one or more substituents independently selected from R7;
• R6 is —H or C1-6 alkyl;
• R7 is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, halo, oxo, cyano, hydroxy, —C(O)R9, —C(O)OR9, —C(O)NR10R11, —OR9, —OC(O)R9, —OC(O)NR10R11, —SR9, —S(O)R9, —S(O)2R9, —S(O)(═NH)R10, —S(O)2NR10R11, —NR10R11, —N(R6)NR10R11, —N(R6)OR9, —N(R6)C(O)R9, —N(R6)C(O)OR9, —N(R6)C(O)NR10R11, —N(R6)S(O)2R9, —N(R6)S(O)2NR10R11, or —P(O)R12R13;
• R9 is —H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl;
• Each R10 and R11 is independently —H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl, or R10 and R11 are taken together with the nitrogen atom to which they are attached to form a 4- to 12-membered heterocyclyl optionally substituted with one or more groups selected from the group consisting of halo, hydroxyl, alkyl, alkenyl, alkynyl, haloalkyl, hydroxyalkyl, —CN, —NO2, —NR10R11, —NR10C(═O)R9, —NR10C(═O)NR10R11, —NR10C(═O)OR9, —OR9, —C(═O)R9, —C(═O)OR9, —C(═O)NR10R11, —OC(═O)R9, —OC(═O)OR9, and —OC(═O)NR10R11;
• Each R12 and R13 is independently C1-6 alkyl, C1-6 alkoxy, C3-8 cycloalkyl, aryl, heteroaryl, heterocyclyl, or R12 and R13 are taken together with the phosphorus atom to which they are attached to form a 4- to 8-membered heterocyclyl optionally substituted with one or more groups selected from the group consisting of halo, hydroxyl, alkyl, alkenyl, alkynyl, haloalkyl, hydroxyalkyl, —CN, —NO2, —NR10R11, —NR10C(═O)R9, —NR10C(═O)NR10R11, —NR10C(═O)OR9, —OR9, —C(═O)R9, —C(═O)OR9, —C(═O)NR10R11, —OC(═O)R9, —OC(═O)OR9, and —OC(═O)NR10R11;
• Het is selected from the group consisting of:
• Each of Ra, Rb and Rc is independently —H, -D, halo, CF3, CF2H, CH2F, CN, OR9 or NR10R11;
• R2 is —H, -D, —CD3, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, halo, hydroxyl, —CD2OH, —CN, —NO2, haloalkyl, trimethylsilylethoxymethyl, —C(O)R9, —C(O)OR9, —C(O)NR10R11, —OR9, —OC(O)R9, —OC(O)NR10R11, —SR9, —S(O)R9, —S(O)2R9, —S(O)(═NH)R10, —S(O)2NR10R11, —NR10R11, —N(R6)NR10R11, —N(R6)OR9, —N(R6)C(O)R9, —N(R6)C(O)R9, —N(R6)C(O)OR9, —N(R6)C(O)NR10R11, —N(R6)S(O)2R9, —N(R6)S(O)2NR10R11, or —P(O)R12R13, wherein the C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with one or more groups selected from the group consisting of halo, hydroxyl, alkyl, alkenyl, alkynyl, haloalkyl, hydroxyalkyl, —CN, —NO2, —NR10R11, —NR10c(═O)R9, —NR10C(═O)NR10R11, —NR10C(═O)OR9, —OR9, —C(═O)R9, —C(═O)OR9, —C(═O)NR10R11, —OC(═O)R9, —OC(═O)OR9, and —OC(═O)NR10R11;
• R3 is —H, -D, —CD3, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, halo, cyano, hydroxy, —CH2OH, —CD2OH, —OH, —CN, —NO2, haloalkyl, —C(O)R9, —C(O)OR9, —C(O)NR10R11, —OR9, —OC(O)R9, —OC(O)NR10R11, —SR9, —S(O)R9, —S(O)2R9, —S(O)(═NH)R10, —S(O)2NR10R11, —NR10R11, —N(R6)NR10R11, —N(R6)OR9, —N(R6)C(O)R9, —N(R6)C(O)OR9, —N(R6)C(O)NR10R11, —N(R6)S(O)2R9, —N(R6)S(O)2NR10R11, or —P(O)R12R13;
• M is a bond, —O—, —S—, or —NR6—;
• R6 is —H or C1-6 alkyl;
• R4 is —H, -D, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, halo, cyano, hydroxy, —C(O)R9, —C(O)OR9, —C(O)NR10R11, — —S(O)2R9, —S(O)(═NH)R10, —S(O)2NR10R11, or —P(O)R12R13, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with one or more groups selected from the group consisting of halo, hydroxyl, alkyl, alkenyl, alkynyl, haloalkyl, hydroxyalkyl, —CN, —CD3, —NO2, —NR10R11, —NR10C(═O)R9, —NR10C(═O)NR10R11, —NR10C(═O)OR9, —NR10S(O)2R9, —OR9, —C(═O)R9, —C(═O)OR9, —C(═O)NR10R11, —OC(═O)R9, —OC(═O)OR9, and —OC(═O)NR10R11;
• and
• R5 is —H, -D, —CD3, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, cycloalkyl, halo, hydroxyl, —CH2OH, —CD2OH, —CN or haloalkyl.