Probucol derivative, preparation method therefor and use thereof

A probucol derivative having a structure represented by general formula III:

• herein R1 and R2 are selected from the group consisting of hydrogen, an alkyl group and an alkoxy group, where the alkyl or alkoxy group is optionally substituted with a hydroxyl group, a cycloalkyl group, an alkenyl group, an ester group, a carboxylic group, a cyano group, an amino group, a nitro group, an amide group, a sulfonyl group, —ONO2, an ether group, an aryl group, a heteroaryl group or halogen;
• and the amino group is optionally substituted with an alkyl group or a cycloalkyl group;
• R5 and R6 are selected from the group consisting of an alkyl group, an alkenyl group, and an aryl group, where the alkyl group, alkenyl group, or aryl group is optionally substituted with a hydroxyl group, an alkyl group, an alkenyl group, an acyl group, an ester group, a carboxylic group, a cyano group, an amino group, a nitro group or halogen;
• n is an integer of 1 to 4;
• X is O;
• and
• R7 is selected from the group consisting of a hydroxyl group, a cycloalkyl group, an alkenyl group, an amide group, an ester group, a cyano group, an amino group, a nitro group, halogen, a saturated heterocyclic group, an aryl group and a heteroaryl group.

A probucol derivative having a structure represented by general formula IV:

• herein R1, R2, R3 and R4 are selected from the group consisting of hydrogen, an alkyl group and an alkoxy group, where the alkyl or the alkoxy group is optionally substituted with a hydroxyl group, a cycloalkyl group, an alkenyl group, an ester group, a carboxylic group, a cyano group, an amino group, a nitro group, an amide group, a sulfonyl group, —ONO2, an ether group, an aryl group, a heteroaryl group or halogen;
• and the amino group is optionally substituted with an alkyl group or a cycloalkyl group;
• M is —CO(CH2)mCONHR14, where m is an integer of 2 to 4;
• R14 is an alkyl group, an aryl group or a heteroaryl group;
• the alkyl group is optionally substituted with a carboxylic group, a sulfonic acid group, —ONO2, an amide group or a cyano group;
• and
• R5 and R6 are selected from the group consisting of an alkyl group, an alkenyl group and an aryl group, where the alkyl group, alkenyl group or aryl group is optionally substituted with a hydroxyl group, an alkyl group, an alkenyl group, an amide group, an ester group, a carbonyl group, a cyano group, an amino group, a nitro group or halogen;
• and the amino group is optionally substituted with branched or linear alkyl group containing C1-C6 or a 3- to 5-membered cycloalkyl group.

A probucol derivative having a structure represented by general formula V:

• herein R1, R2 and R3 are selected from the group consisting of hydrogen, an alkyl group and an alkoxy group, where the alkyl or the alkoxy group is optionally substituted with a hydroxyl group, a cycloalkyl group, an alkenyl group, an ester group, a carboxylic group, a cyano group, an amino group, a nitro group, an amide group, a sulfonyl group, —ONO2, an ether group, an aryl group, a heteroaryl group or halogen;
• and the amino group is optionally substituted with an alkyl group or a cycloalkyl group;
• R8 and R9 are selected from the group consisting of a C1-C6 linear or branched alkyl group, a cycloalkyl group, an aryl group and a heteroaryl group;
• X is NH, N, O or S;
• Y is a heteroaryl group, —CH2— or —C(O);
• when X is NH, O or S, one instance of —Y(CHR10)pR11 is absent;
• p is an integer from 0 to 6;
• and
• R10 and R11 are selected from the group consisting of hydrogen, an amino group, an aryl group, a heteroaryl group and an alkyl group, where the amino group, aryl group, heteroaryl group or alkyl group is optionally substituted with halogen, a hydroxyl group, a saturated heterocyclic hydrocarbyl group, an alkenyl group, a cyano group, an aryl group, a heteroaryl group, —NR15R16, —OR15, —COOR15, —CONR15R16, —NR15COR16, —SO2R15, —ONO2, —SO3H, —CO2H or —NR15SO2R16;
• the saturated heterocyclic hydrocarbyl group is selected from a 4- to 12-membered saturated monocyclic, bicyclic or tricyclic group having at least one carbon atom and at least one heteroatom;
• the at least one heteroatom is selected from N, O or S;
• the number of the at least one heteroatom is 1 to 4;
• R15 and R16 are selected from the group consisting of a hydroxyl group, an alkyl group, a cycloalkyl group, an alkenyl group, an amide group, an ester group, a carboxylic group, a sulfonic acid group, a cyano group, an amino group, a nitro group, halogen, an aryl group and an heteroaryl group.