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US 11,649,214 B2Granted
Inhibitors of the notch transcriptional activation complex kinase (“NACK”) and methods for use of the same
AssigneeUniversity of Miami
InventorsAnthony J. Capobianco, Stephan C. Schürer, Xiaoxia Zhu, Tanya T. Kelley
Life of this patent
Estimating the term…
Abstract
Disclosed herein are Notch transcriptional activation complex kinase (“NACK”) inhibitors, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein include compounds of Formula (la) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.
Claims20
A compound of Formula (Ia), or a pharmaceutically acceptable salt thereof:
- wherein:
- A is C1-4alkyl or
- X is CH or N;
- Y is CH2 or N, and when X is N, then Y is CH2;
- m is 0 or 1, and when m is 1 then Y is CH2;
- n is 0 or 1;
- R1 is H, C1-6alkyleneC(═O)R6, halo, cyano, aryloxy, amino, C0-3alkylene-amido, carbamyl, S-thiocarbamyl, or ureido;
- R2 is H, halo, C1-6alkyl, C3-8cycloalkyl, or heteroaryl;
- each R3 and R4 independently is H, C1-6 alkyl, or C1-3aralkyl, or R3 and R4 and the nitrogen to which they are attached join together to form a 3-6 membered ring optionally comprising 1 to 3 additional heteroatoms selected from N, 0, and S;
- R5 is H, or R1 and R5 together with the atoms to which they are attached form a 5- or 6-membered heterocyclic ring comprising 1 to 3 ring heteroatoms selected from N, O, and S;
- R6 is OH, C1-6alkyl, or OC1-6alkyl;
- and
- R7 is H, halo or amino;
- with the proviso that the compound is not
11 more elements
A compound listed in Table A, Table B, Table C, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.