Vesicles comprising a PTEN inhibitor and uses of same
AssigneesTechnion Research & Development Foundation Limited, Ramot at Tel-Aviv University Ltd.
InventorsShulamit Levenberg, Shaowei Guo, Daniel Offen, Nisim Perets
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Abstract
The present invention provides pharmaceutical compositions comprising membrane vesicles, including extracellular vesicles including those referred to as exosomes, loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor. Methods of treating neurological diseases, disorders or conditions using the extracellular vesicles are provided. Isolated extracellular vesicles loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor are provided as well.
Claims8
A pharmaceutical composition for the treatment of neuronal injury or damage comprising extracellular vesicles loaded with an exogenous inhibitor of phosphatase and tensin homolog (PTEN) expression selected from siRNA targeting PTEN mRNA and shRNA targeting PTEN mRNA, wherein the extracellular vesicles are derived from bone marrow-derived mesenchymal stem cells (MSCs).
Dependencies are inferred from the claim text.