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US 11,643,629 B2Granted
Tangential flow depth filtration systems and methods of filtration using same
AssigneeRepligen Corporation
InventorsMichael Bransby, Derek Carroll
Life of this patent
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Abstract
The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.
Claims21
A method of filtering a fluid, comprising:
- performing alternating tangential flow (ATF) of a fluid through a tangential flow depth filter (TFDF) at a feed flow rate, the TFDF comprising a thick-walled hollow fiber, and
- controlling the feed flow rate of the fluid so that the flowing fluid undergoes turbulent flow.
A method of filtering a fluid, comprising:
- performing alternating tangential flow (ATF) of a fluid through a tangential flow depth filter (TFDF) in a pulsatile manner, the TFDF comprising a thick-walled hollow fiber with a porous wall, and
- controlling a feed flow rate of the fluid so that the flowing fluid undergoes turbulent flow.
A method of filtering a fluid, comprising:
- performing alternating tangential flow (ATF) of a fluid through a tangential flow depth filter (TFDF) using an ATF pump, wherein the TFDF comprises a thick-walled hollow fiber comprising at least one of a plurality of filaments and a plurality of particles formed into a tubular shape, and
- controlling a feed flow rate of the fluid such that the flowing fluid undergoes turbulent flow.
Dependencies are inferred from the claim text.