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US 11,643,628 B2Granted
Tangential flow depth filtration systems and methods of filtration using same
AssigneeRepligen Corporation
InventorsMichael Bransby, Derek Carroll
Life of this patent
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Abstract
The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.
Claims18
A method of filtering a fluid, comprising:
- passing a fluid through a tangential flow depth filter (TFDF) comprising a thick-walled hollow fiber with a porous wall formed by assembling a plurality of filaments into a tubular shape;
- wherein the fluid is passed through the TFDF in a pulsatile manner, the pulsatile manner comprising at least about 200 cycles per minute.
A method of filtering a fluid, comprising:
- flowing a fluid through a tangential flow depth filter (TFDF) in a pulsatile manner, the TFDF comprising a thick-walled hollow fiber with a porous wall;
- wherein the pulsatile manner comprises at least about 200 cycles per minute.
A method of filtering a fluid, comprising:
- flowing a fluid through a tangential flow depth filter (TFDF) comprising a thick-walled hollow fiber such that the flowing fluid comprises a Reynold's number at a feed of the hollow fiber greater than about 2263.
Dependencies are inferred from the claim text.