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US 11,643,441 B1Granted
Nucleic acid vaccines for varicella zoster virus (VZV)
AssigneeModernaTX, Inc.
InventorsGiuseppe Ciaramella, Sayda Mahgoub Elbashir
Life of this patent
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Abstract
Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include at least one RNA polynucleotides having an open reading frame encoding at least one varicella zoster virus (VZV) antigen. Methods for preparing and using such vaccines are also described.
Claims18
A messenger ribonucleic acid (mRNA) vaccine composition comprising;
- (a) an mRNA polynucleotide comprising an open reading frame encoding a varicella zoster virus (VZV) gE protein;
- and
- (b) a lipid nanoparticle,
- wherein the lipid nanoparticle comprises 40-60 mol % ionizable cationic lipid, 5-15 mol % neutral lipid, 30-50 mol % cholesterol, and 0.5-3 mol % polyethylene glycol (PEG)-modified lipid.
1 more element
A messenger ribonucleic acid (mRNA) vaccine composition comprising;
- (a) an mRNA polynucleotide comprising an open reading frame (ORF) encoding a varicella zoster virus (VZV) gE protein and;
- a
- (b) lipid nanoparticle,
- wherein the lipid nanoparticle comprises 40-60 mol % ionizable cationic lipid, 5-15 mol % neutral lipid, 30-50 mol % cholesterol, and 0.5-3 mol % polyethylene glycol (PEG)-modified lipid, and
- wherein 100% of uracil in the ORF comprises a 1-methylpseudouridine in the carbon-5 position of the uracil.
2 more elements
A messenger ribonucleic acid (mRNA) vaccine composition comprising:
- (a) an mRNA polynucleotide comprising an open reading frame (ORF) encoding a varicella zoster virus (VZV) gE protein that comprises the amino acid sequence of SEQ ID NO:
- 38;
- and
- (b) a lipid nanoparticle,
- wherein the lipid nanoparticle comprises 40-60 mol % ionizable cationic lipid, 5-15 mol % DSPC lipid, 30-50 mol % cholesterol, and 0.5-3 mol % PEG-distearoyl glycerol, and
- wherein 100% of uracil in the ORF comprises a 1-methylpseudouridine in the carbon-5 position of the uracil.
3 more elements
Dependencies are inferred from the claim text.