Neuroactive steroids and compositions thereof
AssigneeSage Therapeutics, Inc.
InventorsFrancesco G. Salituro, Maria Jesus Blanco-Pillado, Marshall Lee Morningstar
Life of this patent
Estimating the term…
Abstract
Provided herein is a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, R5, R6a, R6b, R7a, R7a, R11a, R11b, R12a, R12b, R16a, R16b, R19, R11a, R22, RX, RY and n are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds, e.g., in the treatment of CNS-related disorders.
Claims25
A compound of Formula (I-e6):
- or a pharmaceutically acceptable salt thereof;
- wherein:
- each of R2a, R2b, R15a,and R15b is hydrogen;
- R3 is unsubstituted C1-3 alkyl, —CH2OCH3, or —CH2OCH2CH3;
- R19 is hydrogen, methyl, or ethyl;
- RX is —OH;
- RY is methyl;
- and
- R22 is —CN.
A compound selected from
- Com-
- pound
- No.
- Structure
- 2
- 3
- 7
- 11
- 15
- 24
- 26
- or a pharmaceutically acceptable salt thereof.
A compound selected from
- Com-
- pound
- No.
- Structure
- 29
- 42
- 44
- or a pharmaceutically acceptable salt thereof.
A compound of the formula
- or a pharmaceutically acceptable salt thereof.
A compound of the formula
- or a pharmaceutically acceptable salt thereof.
A compound of the formula
- or a pharmaceutically acceptable salt thereof.
A compound of the formula
- or a pharmaceutically acceptable salt thereof.
A compound of the formula
- or a pharmaceutically acceptable salt thereof.
A compound of the formula
- or a pharmaceutically acceptable salt thereof.
A compound of the formula
- or a pharmaceutically acceptable salt thereof.
A compound of the formula
- or a pharmaceutically acceptable salt thereof.
A compound of the formula
- or a pharmaceutically acceptable salt thereof.
A compound of the formula
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.