Inhibitors of alpha 2 beta 1 integrin and methods of use thereof

A compound, or a pharmaceutically acceptable salt thereof or a prodrug thereof, having the formula:

• wherein
• R2 is hydrogen or substituted or unsubstituted alkyl;
• R5 is unsubstituted C1-C3 alkyl;
• R10.1 is hydrogen, halogen, —CX10.13, —CHX10.12, —CH2X10.1, —OCX10.13, —OCH2X10.1, —OCHX10.12, —CN, —SOn10.1R10.1D, —SOv10.1NR10.1AR10.1B, —NHC(O)NR10.1AR10.1B, —N(O)m10.1, —NR10.1AR10.1B, —C(O)R10.1C, —C(O)OR10.1C, —C(O)NR10.1AR10.1B, —OR10.1D, —SR10.1D, —NR10.1ASO2R10.1D, —NR10.1AC(O)R10.1C, —NR10.1AC(O)OR10.1C, —NR10.1AOR10.1C, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R10.2 is hydrogen, halogen, —CX10.23, —CHX10.22, —CH2X10.2, —OCX10.23, —OCH2X10.2, —OCHX10.22, —CN, —SOn10.2R10.2D, —SOv10.2NR10.2AR10.2B, —NHC(O)NR10.2AR10.2B, —N(O)m10.2, —NR10.2AR10.2B, C(O)R10.2C, —C(O)OR10.2C, —C(O)NR10.2AR10.2B, —OR10.2D, —SR10.2D, —NR10.2ASO2R10.2D, —R10.2AC(O)R10.2C, —NR10.2AC(O)OR10.2C, —NR10.2AOR10.2C, —N3, -L10.2-R22, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R10.3 is hydrogen, halogen, —CX10.33, —CHX10.32, —CH2X10.3, —OCX10.33, —OCH2X10.3, —OCHX10.32, —CN, —SOn10.3R10.3D, —SOv10.3NR10.3AR10.3B, —NHC(O)NR10.3AR10.3B, —N(O)m10.3, —NR10.3AR10.3B, —C(O)R10.3C, —C(O)OR10.3C, —C(O)NR10.3AR10.3B, —OR10.3D, —SR10.3D, —NR10.3ASO2R10.3D, —NR10.3AC(O)R10.3C, —NR10.3AC(O)OR10.3C, —NR10.3AOR10.3C, —N3, -L10.3-R23, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R10.4 is hydrogen, halogen, —CX10.43, —CHX10.42, —CH2X10.4, —OCX10.43, —OCH2X10.4, —OCHX10.42, —CN, —SOn10.4R10.4D, —SOv10.4NR10.4AR10.4B, —NHC(O)NR10.4AR10.4B, —N(O)m10.4, —NR10.4AR10.4B, —C(O)R10.4C, —C(O)OR10.4C, —C(O)NR10.4AR10.4B, —OR10.4D, —SR10.4D, —NR10.4ASO2R10.4D, —NR10.4AC(O)R10.4C, —NR10.4AC(O)OR10.4C, —NR10.4AOR10.4C, —N3, -L10.4-R24, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R10.5 is hydrogen, halogen, —CX10.5, —CHX10.52, —CH2X10.5, —OCX10.53, —OCH2X10.5, —OCHX10.52, —CN, —SOn10.5R10.5D, —SOv10.5NR10.5AR10.5B, —NHC(O)NR10.5AR10.5B, —N(O)m10.5, —NR10.5AR10.5B, —C(O)R10.5C, —C(O)OR10.5C, —C(O)NR10.5AR10.5B, —OR10.5D, —SR10.5D, —NR10.5ASO2R10.5D, —NR10.5AC(O)R10.5C, —NR10.5AC(O)OR10.5C, —NR10.5AOR10.5C, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R21 is independently oxo, halogen, —CX213, —CHX212, —CH2X21, —OCX213, —OCH2X21, —OCHX212, —CN, —SOn21R21D, —SOv21NR21AR21B, —NHC(O)NR21AR21B, —N(O)m21, —NR21AR21B, C(O)R21C, —C(O)OR21C, —C(O)NR21AR21B, —OR21D, —SR21D, —NR21ASO2R21D, —NR21AC(O)R21C, —NR21AC(O)OR21C, —NR21AOR21C, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• L10.2, L10.3, and L10.4 are independently a bond, —NH—, —S—, —O—, —C(O)—, —C(O)O—, —OC(O)—, —NHC(O)—, —C(O)NH—, —NHC(O)O—, —OC(O)NH—, —NHC(O)NH—, —NHC(NH)NH—, —S(O)2—, —NHS(O)2—, —S(O)2NH—, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene;
• R22, R23 and R24 are independently substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• L100 is a bond, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene;
• R100 is hydrogen, halogen, —CX1003, —CHX1003, —CH2X100, —OCX1003, —OCH2X100, —OCHX1002, —CN, —SOn100R100D, —SOv100NR100AR100B, —NHC(O)NR100AR100B, —N(O)m100, —NR100AR100B, —C(O)R100C, —C(O)OR100C, —C(O)NR100AR100B, —OR100D, —SR100D, —NR100ASO2R100D, —NR100AC(O)R100C, —NR100AC(O)OR100C, —NR100AOR100C, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R10.1A, R10.1B, R10.1C, R10.1D, R10.2A, R10.2B, R10.2C, R10.2D, R10.3A, R10.3B, R10.3C, R10.3D, R10.4A, R10.4B, R10.4C, R10.4D, R10.5A, R10.5B, R10.5C, R10.5D, R21A, R21B, R21C, R21D, R100A, R100B, R100C, and R100D are independently hydrogen, halogen, —CCl3, —CBr3, —CF3, —CI3, —CH2Cl, —CH2Br, —CH2F, —CH2I, —CHCl2, —CHBr2, —CHF2, —CHI2, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —OSO3H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —OCCl3, —OCBr3, —OCF3, —OCI3, —OCH2Cl, —OCH2Br, —OCH2F, —OCH2I, —OCHCl2, —OCHBr2, —OCHF2, —OCHI2, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R10.1A and R10.1B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R10.2A and R10.2B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R10.3A and R10.3B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R10.4A and R10.4B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R10.5A and R10.5B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R21A and R21B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R100A and R100B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• n10.1, n10.2, n10.3, n10.4, n10.5, n21, and n100 are independently an integer from 0 to 4;
• m10.1, m10.2, m10.3, m10.4, m10.5, m21, m100, v10.1, v10.2, v10.3, v10.4, v10.5, v21, and v100 are independently 1 or 2;
• X10.1, X10.2, X10.3, X10.4, X10.5, X21, and X100 are independently —F, —Cl, —Br, or —I;
• z21 is an integer from 0 to 5;
• and
• wherein at least one of R10.1 or R10.5 is not hydrogen.

A compound, or a pharmaceutically acceptable salt thereof or a prodrug thereof, having the formula:

• wherein
• Ring A is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
• R2 is hydrogen or substituted or unsubstituted alkyl;
• R5 is hydrogen or unsubstituted C1-C3 alkyl;
• L5 is a bond or unsubstituted C1-C3 alkylene;
• R10.1 is hydrogen, halogen, —CX10.13, —CHX10.12, —CH2X10.1, —OCX10.13, —OCH2X10.1, —OCHX10.12, —CN, —SOn10.1R10.1D, —SOv10.1NR10.1AR10.1B, —NHC(O)NR10.1AR10.1B, —N(O)m10.1, —NR10.1AR10.1B, C(O)R10.1C, —C(O)OR10.1C, —C(O)NR10.1AR10.1B, —OR10.1D, —SR10.1D, —NR10.1ASO2R10.1D, —NR10.1AC(O)R10.1C, —NR10.1AC(O)OR10.1C, —NR10.1AOR10.1C, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R10.2 is hydrogen, halogen, —CX10.23, —CHX10.22, —CH2X10.2, —OCX10.23, —OCH2X10.2, —OCHX10.22, —CN, —SOn10.2R10.2D, —SOv10.2NR10.2AR10.2B, —NHC(O)NR10.2AR10.2B, —N(O)m10.2, —NR10.2AR10.2B, C(O)R10.2C, —C(O)OR10.2C, C(O)NR10.2AR10.2B, —OR10.2D, —SR10.2D, —NR10.2ASO2R10.2D, —NR10.2AC(O)R10.2C, —NR10.2AC(O)OR10.2C, —NR10.2AOR10.2C, —N3, -L10.2-R22, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R10.3 is hydrogen, halogen, —CX10.33, —CHX10.32, —CH2X10.3, —OCX10.33, —OCH2X10.3, —OCHX10.32, —CN, —SOn10.3R10.3D, —SOv10.3NR10.3AR10.3B, —NHC(O)NR10.3AR10.3B, —N(O)m10.3, —NR10.3AR10.3B, C(O)R10.3C, —C(O)OR10.3C, —C(O)NR10.3AR10.3B, —OR10.3D, —SR10.3D, —NR10.3ASO2R10.3D, —NR10.3AC(O)R10.3C, —NR10.3AC(O)OR10.3C, —NR10.3AOR10.3C, —N3, -L10.3-R23, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R10.5 is hydrogen, halogen, —CX10.53, —CHX10.52, —CH2X10.5, —OCX10.53, —OCH2X10.5, —OCHX10.52, —CN, —SOn10.5R10.5D, SOv10.5NR10.5AR10.5B, —NHC(O)NR10.5AR10.5B, —N(O)m10.5, —NR10.5AR10.5B, —C(O)R10.5C, —C(O)OR10.5C, —C(O)NR10.5AR10.5B, —OR10.5D, —SR10.5D, —NR10.5ASO2R10.5D, —NR10.5AC(O)R10.5C, —NR10.5AC(O)OR10.5C, —NR10.5AOR10.5C, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R10.6 is independently oxo, halogen, —CX10.63, —CHX10.62, —CH2X10.6, —OCX10.63, —OCH2X10.6, —OCHX10.62, —CN, —SOn10.6R10.6D, —SOv10.6NR10.6AR10.6B, —NHC(O)NR10.6AR10.6B, —N(O)m10.6, —NR10.6AR10.6B, —C(O)R10.6C, —C(O)OR10.6C, —C(O)NR10.6AR10.6B, —OR10.6D, —SR10.6D, —NR10.6ASO2R10.6D, —NR10.6AC(O)R10.6C, —NR10.6AC(O)OR10.6C, —NR10.6AOR10.6C, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R21 is independently oxo, halogen, —CX213, —CHX212, —CH2X21, —OCX213, —OCH2X21, —OCHX212, —CN, —SOn21R21D, —SOv21NR21AR21B, —NHC(O)NR21AR21B, —N(O)m21, —NR21AR21B, —C(O)R21C, —C(O)OR21C, —C(O)NR21AR21B, —OR21D, SR21D, —NR21ASO2R21D, —NR21AC(O)R21C, —NR21AC(O)OR21C, —NR21AOR21C, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• L10.2 and L10.3 are independently a bond, —NH—, —S—, —O—, —C(O)—, —C(O)O—, —OC(O)—, —NHC(O)—, —C(O)NH—, —NHC(O)O—, —OC(O)NH—, —NHC(O)NH—, —NHC(NH)NH—, —S(O)2—, —NHS(O)2—, —S(O)2NH—, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene;
• R22 and R23 are independently substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• L100 is a bond, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene;
• R100 is hydrogen, halogen, —CX1003, —CHX1002, —CH2X100, —OCX1003, —OCH2X100, —OCHX1002, —CN, —SOn100R100D, —SOv100NR100AR100B, —NHC(O)NR100AR100B, —N(O)m100, —NR100AR100B, —C(O)R100C, —C(O)OR100C, —C(O)NR100AR100B, —OR100D, —SR100D, —NR100ASO2R100D, —NR100AC(O)R100C, —NR100AC(O)OR100C, —NR100AOR100C, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R10.1A, R10.1B, R10.1C, R10.1D, R10.2A, R10.2B, R10.2C, R10.2D, R10.3A, R10.3B, R10.3C, R10.3D, R10.5A, R10.5B, R10.5C, R10.5D, R10.6A, R10.6B, R10.6C, R10.6D, R21A, R21B, R21C, R21D, R100A, R100B, R100C, and R100D are independently hydrogen, halogen, —CCl3, —CBr3, —CF3, —CI3, —CH2Cl, —CH2Br, —CH2F, —CH2I, —CHCl2, —CHBr2, —CHF2, —CHI2, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —OSO3H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —OCCl3, —OCBr3, —OCF3, —OCI3, —OCH2Cl, —OCH2Br, —OCH2F, —OCH2I, —OCHCl2, —OCHBr2, —OCHF2, —OCHI2, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R10.1A and R10.1B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R10.2A and R10.2B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R10.3A and R10.3B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R10.5A and R10.5B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R10.6A and R10.6B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R21A and R21B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R100A and R100B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• n10.1, n10.2, n10.3, n10.5, n10.6, n21, and n100 are independently an integer from 0 to 4;
• m10.1, m10.2, m10.3, m10.5, m10.6, m21, m100, v10.1, v10.2, v10.3, v10.5, v10.6, v21, and v100 are independently 1 or 2;
• X10.1, X10.2, X10.3, X10.5, X10.6, X21, and X100 are independently —F, —Cl, —Br, or —I;
• z10.6 is an integer from 0 to 6;
• z21 is an integer from 0 to 11;
• and
• wherein at least one of R10.1 or R10.5 is not hydrogen.

A compound, or a pharmaceutically acceptable salt thereof or a prodrug thereof, having the formula:

• wherein
• R2 is hydrogen or substituted or unsubstituted alkyl;
• R5 is hydrogen or unsubstituted C1-C3 alkyl;
• R10.1 is hydrogen, halogen, —CX10.13, —CHX10.12, —CH2X10.1, —OCX10.13, —OCH2X10.1, —OCHX10.12, —CN, —SOn10.1R10.1D, —SOv10.1NR10.1AR10.1B, —NHC(O)NR10.1AR10.1B, —N(O)m10.1, —NR10.1AR10.1B, C(O)R10.1C, —C(O)OR10.1C, —C(O)NR10.1AR10.1B, —OR10.1D, —SR10.1D, —NR10.1ASO2R10.1D, —NR10.1AC(O)R10.1C, —NR10.1AC(O)OR10.1C, —NR10.1AOR10.1C, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R10.2, R10.3, and R10.4 are independently hydrogen, halogen, or —CF3;
• R10.5 is hydrogen, halogen, —CX10.53, —CHX10.52, —CH2X10.5, —OCX10.53, —OCH2X10.5, —OCHX10.52, —CN, —SOn10.5R10.5D, SOv10.5NR10.5AR10.5B, —NHC(O)NR10.5AR10.5B, —N(O)m10.5, —NR10.5AR10.5B, —C(O)R10.5C, —C(O)OR10.5C, —C(O)NR10.5AR10.5B, —OR10.5D, —SR10.5D, —NR10.5ASO2R10.5D, —NR10.5AC(O)R10.5C, —NR10.5AC(O)OR10.5C, —NR10.1AOR10.5C, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R21 is independently oxo, halogen, —CX213, —CHX212, —CH2X21, —OCX213, —OCH2X21, —OCHX212, —CN, —SOn21R21D, —SOv21NR21AR21B, —NHC(O)NR21AR21B, —N(O)m21, —NR21AR21B, —C(O)R21C, —C(O)OR21C, —C(O)NR21AR21B, —OR21D, —SR21D, —NR21ASO2R21D, —NR21AC(O)R21C, —NR21AC(O)OR21C, —NR21AOR21C, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• L100 is a bond, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene;
• R100 is hydrogen, halogen, —CX1003, —CHX100, —CH2X100, —OCX1003, —OCH2X100, —OCHX1002, —CN, —SOn100R100D, —SOv100NR100AR100B, —NHC(O)NR100AR100B, —N(O)m100, —NR100AR100B, —C(O)R100C, —C(O)OR100C, —C(O)NR100AR100B, —OR100D, —SR100D, —NR100ASO2R100D, —NR100AC(O)R100C, —NR100AC(O)OR100C, —NR100AOR100C, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R10.1A, R10.1B, R10.1C, R10.1D, R10.3A, R10.3B, R10.4A, R10.4B, R10.5A, R10.5B, R10.5C, R10.5D, R21A, R21B, R21C, R21D, R100A, R100B, R100C, and R100D are independently hydrogen, halogen, —CCl3, —CBr3, —CF3, —CI3, —CH2Cl, —CH2Br, —CH2F, —CH2I, —CHCl2, —CHBr2, —CHF2, —CHI2, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —OSO3H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —OCCl3, —OCBr3, —OCF3, —OCI3, —OCH2Cl, —OCH2Br, —OCH2F, —OCH2I, —OCHCl2, —OCHBr2, —OCHF2, —OCHI2, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R10.1A and R10.1B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R10.3A and R10.3B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R10.4A and R10.4B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R10.5A and R10.5B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R21A and R21B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R100A and R100B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• n10.1, n10.5, n21, and n100 are independently an integer from 0 to 4;
• m10.1, m10.5, m21, m100, v10.1, v10.5, v21, and v100 are independently 1 or 2;
• X10.1, X10.5, X21, and X100 are independently —F, —Cl, —Br, or —I;
• z21 is an integer from 0 to 9;
• n is an integer from 0 to 3;
• and
• wherein at least one of R10.1 or R10.5 is not hydrogen.