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AssigneeThe Regents of the University of Michigan
InventorsAnna A. Schwendeman, Yuqing Eugene Chen, Yanhong Guo, Jifeng Zhang, Wenmin Yuan, Emily Morin
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The present invention relates to nanoparticles complexed with therapeutic agents configured for treating cardiovascular related disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising synthetic HDL (sHDL) nanoparticles carrying therapeutic agents configured for treating cardiovascular related disorders, methods for synthesizing such sHDL nanoparticles, as well as systems and methods utilizing such sHDL nanoparticles (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutic agents, imaging agents, and/or targeting agents (e.g., in cardiovascular disease diagnosis and/or therapy, etc.))).
A composition comprising a synthetic high density lipoprotein(HDL)-therapeutic agent nanoparticle (sHDL-TA),
A composition comprising a synthetic HDL-therapeutic agent-imaging agent nanoparticle (sHDL-TA/IA), wherein the sHDL comprises at least one HDL apolipoprotein and at least one phospholipid, wherein the HDL apolipoprotein is an apolipoprotein A-I (apo A-I) mimetic having the sequence PVLDLFRELLNELLEALKQKLK (SEQ ID NO:
Dependencies are inferred from the claim text.