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US 11,642,308 B2Granted
Ready to use liquid formulation
AssigneeQuVa Pharma, Inc.
InventorsTravis A. Leeah, Jianping Chen, Lijie Zhao
Life of this patent
Estimating the term…
Abstract
Disclosed herein is a ready-to-use liquid, injectable formulation comprising lidocaine and epinephrine. Also disclosed herein is a process for preparing a ready-to-use liquid formulation comprising lidocaine and epinephrine, as well as methods for using the ready-to-use liquid formulation.
Claims20
A ready-to-use liquid formulation comprising:
- lidocaine hydrochloride in an amount of about 5 mg/mL or about 10 mg/mL;
- epinephrine in an amount that ranges from about 10 mcg/mL to about 10.8 mcg/mL;
- sodium chloride in an amount of about 6 mg/mL to about 7 mg/mL;
- sodium metabisulfite in an amount of about 5 mcg/mL to about 5.6 mcg/mL;
- EDTA sodium in an amount of about 0.5 mg/mL to about 0.6 mg/mL;
- optionally N-acetyl-L-cysteine in an amount of about 10 mcg/mL to about 13 mcg/mL;
- citrate buffer in an amount of about 1 to about 10 mM;
- a sufficient amount of sterile water for injection;
- and
- a sufficient amount of a pH adjuster to obtain a pH that ranges from about 6.3 to about 6.5;
- wherein the epinephrine content ranges from about 9 mcg/mL to about 9.7 mcg/mL after storage in a light protected environment for about 60 days to about 90 days at a temperature of about 5° C.
8 more elements
A ready-to-use liquid formulation consisting of:
- lidocaine hydrochloride in an amount of about 5 mg/mL or about 10 mg/mL;
- epinephrine in an amount that ranges from about 10 mcg/mL to about 10.8 mcg/mL;
- sodium chloride in an amount of about 6 mg/mL to about 7 mg/mL;
- sodium metabisulfite in an amount of about 5 mcg/mL to about 5.6 mcg/mL;
- EDTA sodium in an amount of about 0.5 mg/mL to about 0.6 mg/mL;
- optionally N-acetyl-L-cysteine in an amount of about 10 mcg/mL to about 13 mcg/mL;
- citrate buffer in an amount of about 1 to about 10 mM;
- a sufficient amount of sterile water for injection;
- and
- a sufficient amount of a pH adjuster to obtain a pH that ranges from about 6.3 to about 6.4;
- wherein the epinephrine content ranges from about 9 mcg/mL to about 9.7 mcg/mL after storage in a light protected environment for about 60 days to about 90 days at a temperature of about 5° C.
8 more elements
Dependencies are inferred from the claim text.