Compositions and methods for adhesion to surfaces

A method of joining two or more bones, bone fragments, or bone segments with an injectable adhesive composition, the method comprising injecting the adhesive composition in a fluid state onto or into the bones, bone fragments, or bone segments to be joined;

• wherein the adhesive composition comprises an organic phosphate compound, a multivalent metal salt selected from tetracalcium phosphate or tricalcium phosphate, and an aqueous medium, the injectable adhesive composition comprising about 10% to about 35% aqueous medium to provide for a viscosity between 100 cP and 10,000 cP when in the fluid state;
• the multivalent metal salt is provided as a powder;
• and
• the mean particle size of the powder particles is between 0.005 mm and 0.150 mm;
• thereby joining two or more bones, bone fragments, or bone segments.