Probiotics and probiotic compositions for regulating body weight
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsAbhinav Prakash Acharya, Steven R. Little
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Abstract
The present disclosure relates to probiotics and probiotic compositions having modified energy metabolisms (e.g., modifying, metabolizing, or storing energy molecules, e.g., lipids, before the energy molecules are absorbed by a host subject), and thus modulating the absorption of the energy molecules by the host subject. The present disclosure also relates to methods of making such probiotics and probiotic compositions. The present disclosure further relates to methods of regulating (e.g., maintaining or reducing) body weight in a subject (e.g., a subject having a healthy BMI, a subject having an overweight BMI, a subject having an obese BMI), using the probiotics and probiotic compositions disclosed herein.
Claims14
A method of reducing or maintaining bodyweight of a mammalian subject, comprising:
- (a) subjecting bacteria isolated from a saliva or stool sample from the subject to a stress-based directed evolution to generate probiotic bacteria therefrom,
- wherein the stress-based directed evolution comprises culturing the bacteria in increasing lipid concentrations, and
- wherein the probiotic bacteria have an increased fatty acid metabolism and/or increased lipase activity as compared to the bacteria that have not been subjected to the stress-based evolution;
- and
- (b) orally administering to the subject an effective amount of the probiotic bacteria, wherein the probiotic bacteria decrease the amount of lipids that are available for absorption in the gastrointestinal tract of the subject.
A method of inhibiting or reducing a lipid absorption in the gastrointestinal tract of a mammalian subject, comprising:
- (a) subjecting bacteria isolated from a saliva or stool sample from the subject to a stress-based directed evolution to generate probiotic bacteria therefrom,
- wherein the stress-based directed evolution comprises culturing the bacteria in increasing lipid concentrations, and
- wherein the probiotic bacteria have an increased fatty acid metabolism and/or increased lipase activity as compared to the bacteria that have not been subjected to the stress-based evolution;
- and
- (b) orally administering to the subject an effective amount of the probiotic bacteria,
- wherein the probiotic bacteria decrease the amount of lipids that are available for absorption in the gastrointestinal tract of the subject.
Dependencies are inferred from the claim text.