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AssigneeMolecular Devices, LLC
InventorsEmmanuel Israel Fuentes, Gopal Biligeri Avinash, Robert John Graves, Abhijit Vijay Thatte, Afek Kodesh, Jeffery Caron, Sharmistha Das
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The invention relates to a method for a computer device, for detecting an optimal candidate compound based on a plurality of samples comprising a cell line and one or more biomarkers, and a plate map configuration, wherein the plate map configuration is providing locations of samples comprising cell lines exposed to one or more biomarkers and different concentrations of a candidate compound forming at least one concentration gradient, the candidate compound being comprised in a plurality of candidate compounds, said method comprising generating (310) phenotypic profiles of each concentration gradient of each of the plurality of candidate compounds at a plurality of successive points in time to form a plurality of compound profiles, wherein generating phenotypic profiles comprises the steps obtaining (312) image data depicting each sample comprised in the concentration gradient, generating (314) a class-label and a class for each cell of the samples based on the image data, detecting (320) the optimal candidate compound by evaluating a comparison criterion on the plurality of compound profiles. Furthermore, the invention also relates to corresponding computer device, a computer program, and a computer program product.
A method for a computer device, for detecting an optimal candidate compound based on a plurality of samples comprising a cell line and one or more biomarkers, and a plate map configuration, wherein the plate map configuration is providing locations of samples comprising cell lines exposed to one or more biomarkers and different concentrations of a candidate compound forming at least one concentration gradient, the candidate compound being comprised in a plurality of candidate compounds, said method comprising:
A computer device for detecting an optimal candidate compound based on a plurality of samples comprising a cell line, one or more biomarkers, and a plate map configuration, wherein the plate map configuration is providing locations of samples comprising cell lines exposed to one or more biomarkers and different concentrations of a candidate compound forming at least one concentration gradient, the candidate compound being comprised in a plurality of candidate compounds, the computer device comprising:
A computer program product comprising a non-transitory computer-readable storage medium encoded with computer-executable instructions for causing a computer device, when the computer-executable instructions are executed on a processing unit comprised in the computer device, to perform the method steps:
Dependencies are inferred from the claim text.