US 11,635,480 B2 · System and method of robust quantitative susceptibility mapping

Abstract

Exemplary quantitative susceptibility mapping methods, systems and computer-accessible medium can be provided to generate images of tissue magnetism property from complex magnetic resonance imaging data using the Bayesian inference approach, which minimizes a cost function consisting of a data fidelity term and two regularization terms. The data fidelity term is constructed directly from the complex magnetic resonance imaging data. The first prior is constructed from matching structures or information content in known morphology. The second prior is constructed from a region having an approximately homogenous and known susceptibility value and a characteristic feature on anatomic images. The quantitative susceptibility map can be determined by minimizing the cost function. Thus, according to the exemplary embodiment, system, method and computer-accessible medium can be provided for determining magnetic susceptibility information associated with at least one structure.

Claims20

Dependent claims

A method for generating one or more images of an object, the method comprising:

receiving magnetic resonance imaging (MRI) data obtained by a magnetic resonance scanner, wherein the MRI data is complex and comprises magnitude and phase information or real and imaginary information regarding tissue in the object, and Gaussian noise;
calculating a magnetic field experienced by the tissue in the object based on modeling the complex MRI data according to tissue composition;
identifying a region of interest in the tissue that has an approximately uniform susceptibility according to a characteristic feature, wherein the characteristic feature comprises a low value of R2* and/or R2, where the region of interest corresponds to at least a vein;
determining a magnetic susceptibility distribution of the object according to the MRI data and the identified region of interest;
generating image data using the determined magnetic susceptibility distribution;
and
outputting the image data to a display device, a storage device, a network device, or a transmission device, or a combination thereof.

4 more elements

A system for generating one or more images of an object, the system comprising:

a processor;
a display device communicatively coupled to the processor;
an Input/Output (I/O) device communicatively coupled to the processor;
a non-transitory computer storage medium encoded with a computer program, the program comprising instructions that when executed by processor cause the processor to perform operations comprising:
receiving magnetic resonance imaging (MRI) data obtained by a magnetic resonance scanner, wherein the MRI data is complex and comprises magnitude and phase information or real and imaginary information regarding tissue in the object, and Gaussian noise;
calculating a magnetic field experienced by the tissue in the object based on modeling the complex MRI data according to tissue composition;
identifying a region of interest in the tissue that has an approximately uniform susceptibility according to a characteristic feature, wherein the characteristic feature comprises a low value of R2* and/or R2, where the region of interest corresponds to at least a vein;
determining a magnetic susceptibility distribution of the object according to the MRI data and the identified region of interest;
generating image data using the determined magnetic susceptibility distribution;
and
outputting the image data to the display device, a storage device, a network device, or a transmission device, or a combination thereof.

8 more elements

Dependencies are inferred from the claim text.

System and method of robust quantitative susceptibility mapping

Life of this patent

System and method of robust quantitative susceptibility mapping

Life of this patent

Abstract

Claims20