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US 11,635,447 B2Granted
Microscopy imaging
AssigneeAlentic Microscience Inc.
InventorAlan Marc Fine
Life of this patent
Estimating the term…
Abstract
Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels.
Claims17
An apparatus comprising:
- an imaging sensor comprising
- an array of photosensitive pixels at a sensor surface, and
- a first surface configured to receive a specimen;
- a specimen chamber configured to hold the specimen statically during imaging by the imaging sensor;
- and
- a light source configured to illuminate the specimen at a first wavelength in a fluorescence or phosphorescence excitation band of the specimen, wherein the first surface and the sensor surface are arranged such that at least part of the specimen is at a distance from the sensor surface that is less than five times the first wavelength when the specimen is disposed on the first surface,
- wherein the imaging sensor is configured to capture light at a second wavelength in a fluorescence or phosphorescence emission band of the specimen at a time after the specimen has been illuminated at the first wavelength.
4 more elements
A method comprising:
- situating a specimen statically at an imaging sensor, wherein the imaging sensor comprises an array of photosensitive pixels,
- wherein situating the specimen comprises situating the specimen at least partially within a distance from the array of photosensitive pixels that is less than five times a first wavelength, and wherein the first wavelength is in a fluorescence or phosphorescence excitation band of the specimen;
- illuminating the specimen with light of the first wavelength;
- and
- after illumination of the specimen, capturing, using the imaging sensor, while the specimen is held statically, light of a second wavelength in a fluorescence or phosphorescence emission band of the specimen, the light of the second wavelength emitted by the specimen in response to illumination by the light of the first wavelength.
2 more elements
Dependencies are inferred from the claim text.