Functional porous substrates for attaching biomolecules
AssigneeW. L. Gore & Associates, Inc.
InventorsAnit Dutta, Heidi Flannery, William P. Mortimer, Jr.
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Abstract
An expanded polytetrafluoroethylene substrate comprising a microporous microstructure, an interlayer over at least a portion of the microstructure, the interlayer containing a reactive functionality, and a functional layer attached to the interlayer, the interlayer comprising a sol-gel or a polyvinylalcohol. The functional layer of the substrate having functional sites with a density of at least 50 nanomoles/cm2.
Claims20
An expanded polytetrafluoroethylene substrate comprising a microporous microstructure having a fibril length between 0.5 and 5 microns and a thickness of about 250 microns or less, an interlayer over at least a portion of said microstructure, the interlayer containing a reactive functionality, and a functional layer attached to said interlayer,
- said interlayer comprising a sol-gel coating or a polyvinylalcohol,
- said functional layer having functional sites with a density of at least 50 nanomoles/cm2.
A method of creating a functionalized article comprising the steps of:
- providing a microporous substrate comprising expanded polytetrafluorethylene and having a microstructure having a fibril length between 0.5 and 5 microns and a thickness of about 250 microns or less,
- depositing over at least a portion of said microstructure an interlayer comprising a reactive functionality, said interlayer comprising a sol-gel coating or a
- polyvinylalcohol, and
- attaching a functional layer to said interlayer and reacting functional chemistries with the functionality of the interlayer to create functional sites such that said article has a functional site density of at least 50 nanomoles/cm2.
Dependencies are inferred from the claim text.