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US 11,635,428 B2Granted
Molecule detecting device and molecule detecting method
AssigneeKabushiki Kaisha Toshiba
InventorsHiroko Miki, Atsunobu Isobayashi, Yoshiaki Sugizaki
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Abstract
According to one embodiment, a molecule detecting device includes a capturing section, a releasing section, and a detecting section. The capturing section is configured to, by combining a target molecule and a solubilizing agent with each other and thereby creating a composite body, capture the target molecule in a carrier liquid. The releasing section is configured to make the composite body release the target molecule therefrom in the carrier liquid. The detecting section is configured to carry out detection of the target molecule in the carrier liquid.
Claims7
A molecule detecting device comprising:
- a capturing section configured to, by combining a target molecule and a solubilizing agent with each other to thereby create a composite body, capture the target molecule in a carrier liquid;
- a releasing section configured to make the composite body release the target molecule therefrom in the carrier liquid;
- and
- a detecting section configured to carry out detection of the released target molecule in the carrier liquid,
- wherein:
- the releasing section includes a flow path connected, at its one end, to the capturing section, wherein the carrier liquid is introduced into the flow path from the capturing section, and the releasing section includes a light irradiating device irradiating an inside of the flow path with light, a temperature control device heating an inside of the flow path, or a pH adjusting device introducing a pH adjuster into the flow path,
- the detecting section includes a sensor element including a sensitive membrane including a capturing body which specifically combines with the released target molecule, and is configured to detect a variation in the physical amount of the sensitive membrane,
- the solubilizing agent includes amphipathic molecules each of which possesses a hydrophilic section and a hydrophobic section,
- the capturing section includes a first container in which the carrier liquid containing the solubilizing agent is accommodated and into which the target molecule is introduced so as to be contacted with the carrier liquid,
- the molecule detecting device further includes a second container to which another end of the flow path is connected and into which the carrier liquid is introduced, and
- the detecting section is accommodated in the second container.
8 more elements
A molecule detecting device comprising:
- a capturing section configured to, by combining a target molecule and a solubilizing agent with each other to thereby create a composite body, capture the target molecule in a carrier liquid;
- a releasing section configured to make the composite body release the target molecule therefrom in the carrier liquid;
- and
- a detecting section configured to carry out detection of the released target molecule in the carrier liquid,
- wherein:
- the releasing section includes a flow path connected, at its one end, to the capturing section, wherein the carrier liquid is introduced into the flow path from the capturing section, and the releasing section includes a light irradiating device irradiating an inside of the flow path with light,
- the detecting section includes a sensor element including a sensitive membrane including a capturing body which specifically combines with the released target molecule, and is configured to detect a variation in the physical amount of the sensitive membrane,
- the solubilizing agent includes amphipathic molecules each of which possesses a hydrophilic section and a hydrophobic section,
- the capturing section includes a first container in which the carrier liquid containing the solubilizing agent is accommodated and into which the target molecule is introduced so as to be contacted with the carrier liquid,
- the molecule detecting device further includes a second container to which another end of the flow path is connected and into which the carrier liquid is introduced,
- the detecting section is accommodated in the second container, and
- the solubilizing agent comprises dextran-graft-(2-diazo-1,2-naphthoquinone).
9 more elements
A molecule detecting device comprising:
- a capturing section configured to, by combining a target molecule and a solubilizing agent with each other to thereby create a composite body, capture the target molecule in a carrier liquid;
- a releasing section configured to make the composite body release the target molecule therefrom in the carrier liquid;
- and
- a detecting section configured to carry out detection of the released target molecule in the carrier liquid,
- wherein:
- the releasing section includes a flow path connected, at its one end, to the capturing section, wherein the carrier liquid is introduced into the flow path from the capturing section, and the releasing section includes a pH adjusting device introducing a pH adjuster into the flow path,
- the detecting section includes a sensor element including a sensitive membrane including a capturing body which specifically combines with the released target molecule, and is configured to detect a variation in the physical amount of the sensitive membrane,
- the solubilizing agent includes amphipathic molecules each of which possesses a hydrophilic section and a hydrophobic section,
- the capturing section includes a first container in which the carrier liquid containing the solubilizing agent is accommodated and into which the target molecule is introduced so as to be contacted with the carrier liquid,
- the molecule detecting device further includes a second container to which another end of the flow path is connected and into which the carrier liquid is introduced,
- the detecting section is accommodated in the second container, and
- the solubilizing agent comprises odorant-binding protein (OBP).
9 more elements
Dependencies are inferred from the claim text.