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US 11,635,384 B2Granted
Methods and apparatuses for label-free particle analysis
AssigneeKinetic River Corp.
InventorGiacomo Vacca
Life of this patent
Estimating the term…
Abstract
An apparatus to provide a label-free or native particle analysis comprises a light generating system producing first light pulses at a first wavelength and second light pulses at a second wavelength; and a flow cell coupled to the light generating system to convey particles for analysis. The light generating system is configured to chirp at least one of the first light pulses and the second light pulses to analyze the particles.
Claims20
A method of particle analysis, comprising:
- producing, using a light generating system, a first set of light pulses in a first wavelength region and a second set of light pulses in a second wavelength region;
- positively chirping, using the light generating system, the first set of light pulses;
- negatively chirping, using the light generating system, the second set of light pulses;
- combining, using a first optical system, the first set of chirped light pulses and the second set of chirped light pulses into a set of combined chirped light pulses, wherein each of the combined chirped light pulses comprises a first pulse from the first set of chirped light pulses and a second pulse from the second set of chirped light pulses;
- conveying, in a flow, a sample for analysis;
- and
- exposing at least a portion of the sample to a plurality of the combined chirped light pulses.
4 more elements
A method of particle analysis, comprising:
- producing, using a light generating system, a first set of light pulses in a first wavelength region and a second set of light pulses in a second wavelength region;
- positively chirping, using the light generating system, the first set of light pulses;
- negatively chirping, using the light generating system, the second set of light pulses;
- combining, using a first optical system, the first set of chirped light pulses and the second set of chirped light pulses into a set of combined chirped light pulses, wherein each of the combined chirped light pulses comprises a first pulse from the first set of chirped light pulses and a second pulse from the second set of chirped light pulses;
- and
- exposing at least a portion of a sample to a plurality of the combined chirped light pulses.
3 more elements
A method of particle analysis, comprising:
- producing, using a light generating system, a first set of light pulses in a first wavelength region and a second set of light pulses in a second wavelength region;
- positively chirping, using the light generating system, the first set of light pulses;
- negatively chirping, using the light generating system, the second set of light pulses;
- combining, using a first optical system, the first set of chirped light pulses and the second set of chirped light pulses into a set of combined chirped light pulses, wherein each of the combined chirped light pulses comprises a first pulse from the first set of chirped light pulses and a second pulse from the second set of chirped light pulses;
- conveying, in a flow, particles for analysis;
- and
- exposing at least one of the particles to at least one of the combined chirped light pulses.
4 more elements
A method of particle analysis, comprising:
- producing, using a light generating system, a first set of light pulses in a first wavelength region and a second set of light pulses in a second wavelength region;
- positively chirping, using the light generating system, the first set of light pulses;
- negatively chirping, using the light generating system, the second set of light pulses;
- combining, using a first optical system, the first set of chirped light pulses and the second set of chirped light pulses into a set of combined chirped light pulses, wherein each of the combined chirped light pulses comprises a first pulse from the first set of chirped light pulses and a second pulse from the second set of chirped light pulses;
- and
- exposing at least one particle to at least one of the combined chirped light pulses.
3 more elements
Dependencies are inferred from the claim text.