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US 11,635,365 B2Granted
Cell capture system and method of use
AssigneeBio-Rad Laboratories, Inc.
InventorKalyan Handique
Life of this patent
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Abstract
A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
Claims19
A method comprising:
- providing a substrate comprising:
- a sample inlet coupled to an inlet manifold,
- an outlet manifold,
- a set of inlet channels connected to the inlet manifold,
- a set of outlet channels connected to the outlet manifold, and
- a set of chambers in fluid communication with an inlet channel of the set of inlet channels and an outlet channel of the set of outlet channels, the inlet channel paired with the outlet channel, wherein flow from the inlet manifold is configured to reach the outlet manifold only by passing into the set of chambers;
- receiving a sample into the sample inlet;
- sealing the substrate;
- and
- performing a set of processes upon the sample within the set of chambers at the substrate.
7 more elements
Dependencies are inferred from the claim text.