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US 11,634,775 B2Granted
Circulating serum microRNA biomarkers and methods for Alzheimer's disease diagnosis
AssigneeSt. John's University
InventorsSimon Geir Moller, Ketan Shirish Patil, Guido Werner Alves
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Abstract
Biomarkers and methods for identifying, verifying and confirming circulating serum-based microRNAs. The microRNAs (PARKmiRs) can be used to differentiate patient's suffering from Alzheimer's disease (AD) from non-AD patients.
Claims17
A method, comprising the steps of:
- (a) providing a serum sample from a human patient;
- (b) detecting the level of SEQ ID NOs:
- 22, 25, and 27 in the serum sample;
- (c) diagnosing the human patient with Alzheimer's disease when the level of SEQ ID NOs:
- 22, 25 and 77 in the serum sample are decreased in comparison to the level of SEQ ID NOs:
- 22, 25, and 77 in control serum samples obtained from healthy patients;
- and
- (e) administering a cholinesterase inhibitor or a N-methyl-D-aspartate receptor antagonist to said human patient diagnosed with Alzheimer's disease.
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Dependencies are inferred from the claim text.