Analysis of HLA alleles in tumours and the uses thereof
AssigneesThe Francis Crick Institute Limited, University College London, Cancer Research Technology Limited
InventorsCharles Swanton, Nicholas McGranahan, Rachel Rosenthal
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Abstract
The present invention relates to a method for determining whether an HLA allele is lost in a tumour in a subject, wherein said method comprises the step of determining the specific copy number of said HLA allele in said tumour. The invention also relates to a method for treating cancer in a subject, comprising targeting a neoantigen which is predicted to be presented by an HLA molecule encoded by an HLA allele which has been determined not to have been lost in a tumour in said subject.
Claims12
A method of treating cancer in a subject, comprising administering to said subject a therapy targeting a neo-antigen that is predicted to be presented by an HLA molecule encoded by an HLA allele which has been determined not to have been lost in a tumour in said subject, wherein determination of whether said HLA allele has been lost comprises the steps of:
- aligning HLA allele sequence information from a tumour sample from said subject with an HLA allele reference sequence which is based on said subject's HLA type;
- and
- determining the specific copy number of said HLA allele in said tumour.
Dependencies are inferred from the claim text.