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US 11,634,728 B2Granted
Adeno-associated virus (AAV) vector having hybrid HGF gene introduced thereto
AssigneeHelixmith Co., Ltd
InventorsSeung Shin Yu, Jae Gyun Jeong, Jung Hun Lee, Su Bin Kim
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Abstract
The present invention relates to an AAV vector carrying a predetermined hybrid HGF gene sequence. Use of the AAV vector of the present invention allows a hybrid HGF gene to be delivered to a subject at a high delivery yield.
Claims3
An adeno-associated virus (AAV) vector, comprising a foreign nucleic acid sequence consisting of:
- (a) the nucleotide sequence set forth in SEQ ID NO:
- 5;
- or
- (b) a codon-modified nucleotide sequence having homology of at least 80% to the nucleotide sequence set forth in SEQ ID NO:
- 5, wherein said codon-modified nucleotide sequence encodes the same amino acid sequence as the coding region of the nucleotide sequence set forth in SEQ ID NO:
- 5.
3 more elements
Dependencies are inferred from the claim text.