US 11,634,712 B2 · Nucleic acid simultaneously inhibiting expression of mTOR gene and STAT3 gene

Abstract

The present invention relates to a nucleic acid molecule simultaneously inhibiting the expression of mTOR gene and STAT3 gene, and an anticancer pharmaceutical composition comprising the same. More specifically, base-paired siRNA or shRNA of the present invention, designed to simultaneously inhibit the expression of cancer-related mTOR gene and STAT3 gene in order to surmount the problem that siRNA or shRNA does not achieve high therapeutic effects due to the target specificity thereof, has the effect of promoting the death of cancer cells. In addition, the nucleic acid has the effect of synergistically enhancing the apoptosis of cancer cells when used in combination with an anticancer agent, finding useful applications as an anticancer composition or anticancer aid against various carcinomas.

Claims9

Dependent claims

A siRNA or shRNA simultaneously inhibiting the expression of mammalian target of rapamycin (mTOR) gene and signal transducer and activator of transcription 3 (STAT3) gene,

wherein the siRNA or shRNA comprises the sequences represented by SEQ ID NOs:
1 and 2;
SEQ ID NOS:
3 and 4;
SEQ ID NOS:
5 and 6;
SEQ ID NOS:
7 and 8;
SEQ ID NOS:
9 and 10;
SEQ ID NOS:
11 and 12;
SEQ ID NOS:
13 and 14;
SEQ ID NOS:
15 and 16;
or SEQ ID NOs:
17 and 18.

15 more elements

Dependencies are inferred from the claim text.

Facts

Application

17/002,621Filed 25 Aug 2020 · division

Priority

KR 10-2017-001366131 Jan 2017

Published

US 2021/0054378 A125 Feb 2021

Granted

25 Apr 2023

Term ends

Not estimatedThe source records don’t support an estimate.

Classification14 codes

C12N 15/113
DNA or RNA fragments; Modified forms thereof ; Non-coding nucleic acids having a biological activity: non-coding nucleic acids modulating the…
A61K 31/282
Compounds containing heavy metals: platinum compounds
A61K 31/7105
Compounds having three or more nucleosides or nucleotides: natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine,…
A61K 31/713
Compounds having three or more nucleosides or nucleotides: double-stranded nucleic acids or oligonucleotides

Family

PCT/KR2018/001231Parent of this division · filed 29 Jan 2018

US 2021/0054378 A1Pre-grant publication · published 25 Feb 2021

Application16/482,565Parent of this division

US 11,149,272 B2Parent of this division

US 2019/0345497 A1Published application

US 11,634,712 B2This patent

From the US filing history. Foreign family members aren’t listed.

Nucleic acid simultaneously inhibiting expression of mTOR gene and STAT3 gene

Life of this patent

Nucleic acid simultaneously inhibiting expression of mTOR gene and STAT3 gene

Life of this patent

Abstract

Claims9