Zwitterionically modified polymers and hydrogels

A polymer of Formula (IV):

• wherein,
• A is independently selected from a saccharide containing unit and a polyvinyl alcohol containing unit for each monomer unit of the polymer;
• X is selected from the group consisting of O, NH, NR′, C(O), and C1-20 alkylene, wherein C1-20 alkylene is optionally substituted from 1 to 20 times with a substituent selected independently at each occurrence thereof from the group consisting of OH, halogen, cyano, —CF3, and C1-6 alkoxy;
• Q is absent or is a linker;
• Y is
• Z is
• m1 is 0 to 50;
• m2 is 0 to 50;
• m3 is 0 to 50;
• R is C1-20 alkyl;
• R′ is —C(O)—C1-6 alkene;
• k1 is any integer;
• and
• k2 is independently selected for each monomer unit from 0 or 1, with the proviso that at least one k2 is 1;
• wherein the monomers units of the polymer are the same or different.

A zwitterionic polymer of Formula (IIa):

• wherein
• A is independently selected from a saccharide containing unit and a polyvinyl alcohol containing unit for each monomer unit of the polymer;
• X is selected from the group consisting of O, NH, NR′, C(O), and C1-20 alkylene, wherein C1-20 alkylene is optionally substituted from 1 to 20 times with a substituent selected independently at each occurrence thereof from the group consisting of OH, halogen, cyano, —CF3, and C1-6 alkoxy;
• Q is absent or is a linker;
• Y is selected from the group consisting of
• Z is selected from the group consisting of
• m1 is 0 to 50;
• m2 is 0 to 50;
• m3 is 0 to 50;
• R is C1-20 alkyl;
• R′ is —C(O)—C1-6 alkene;
• R1 is C1-20 alkyl;
• R2 is C1-20 alkyl;
• R3 is C1-20 alkyl;
• L1 is selected from the group consisting of O, NH, NR′, C(O), and C1-20 alkylene, wherein C1-20 alkylene is optionally substituted from 1 to 20 times with a substituent selected independently at each occurrence thereof from the group consisting of OH, halogen, cyano, —CF3, and C1-6 alkoxy;
• L2 is absent or is C1-20 alkylene, wherein C1-20 alkylene is optionally substituted from 1 to 20 times with a substituent selected independently at each occurrence thereof from the group consisting of OH, halogen, cyano, —CF3, and C1-6 alkoxy;
• L3 is selected from the group consisting of C1-20 alkylene, C1-20 alkenylene, C3-12 cycloalkenylene, and arylene, wherein arylene is optionally substituted from 1 to 3 times with a substituent selected independently at each occurrence thereof from the group consisting of heteroarylene and heterocyclylene;
• R4 is selected from the group consisting of SH, N3, C2-20 alkenyl, C2-20 alkynyl, C3-12 cycloalkenyl, C3-12 cycloalkynyl, heteroaryl, and heterocyclyl, wherein C2-20 alkenyl, C2-20 alkynyl, C3-12 cycloalkenyl, C3-12 cycloalkynyl, heteroaryl, and heterocyclyl is optionally substituted from 1 to 3 times with a substituent selected independently at each occurrence thereof from the group consisting of H, OH, halogen, cyano, —CF3, and C1-6 alkoxy;
• and
• n1, n2, and n3 are any integer.