Dendritic gold nanoparticles and methods of synthesis
AssigneeThe Board of Regents of the University of Oklahoma
InventorsChuanbin Mao, Lin Wang, Penghe Qiu
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Abstract
A method of producing dendritic gold nanoparticles by combining a gold precursor solution, a reducing agent, and a bifunctional peptide having an amine-rich amino acid sequence into a buffered aqueous solution in a single container, and agitating the mixture causing the formation of the dendritic gold nanoparticles having a surface with a positive charge and a second end portion of the bifunctional peptide exposed on the surface of the dendritic gold nanoparticles. The dendritic gold nanoparticles may be used to deliver therapeutic, diagnostic, and/or immunogenic amino acid sequences as portions of the bifunctional peptide.
Claims7
A method of producing dendritic gold nanoparticles, comprising:
- providing a gold precursor solution, a reducing agent, and a bifunctional peptide, wherein the bifunctional peptide comprises a first end portion comprising an amine-rich amino acid sequence, and a second end portion;
- combining, in a single container, the gold precursor solution, reducing agent, and bifunctional peptide in a buffered aqueous solution at a pH in a range of 6-9 to form a mixture;
- and
- agitating the mixture causing the formation of dendritic gold nanoparticles having a surface with a positive charge and having the second end portion of the bifunctional peptide exposed on the surface of the dendritic gold nanoparticles.
Dependencies are inferred from the claim text.