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US 11,634,505 B2Granted
Antibodies to matrix metalloproteinase 9
AssigneeGilead Sciences, Inc.
InventorsVictoria Smith, Scott McCauley
Life of this patent
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Abstract
The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen-binding fragments thereof, that bind to the matrix metalloproteinase-9 (MMP9) protein (MMP9 is also known as gelatinase-B), such as where the binding proteins comprise an immunoglobulin (Ig) heavy chain (or functional fragment thereof) and an Ig light chain (or functional fragment thereof).
Claims13
An isolated antibody or antigen binding fragment thereof that binds matrix metalloproteinase 9 (MMP9), comprising:
- a heavy chain comprising a heavy chain variable (VH) domain, wherein the VH domain comprises a complementarity-determining region 1 (CDR-H1) comprising the amino acid sequence set forth in SEQ ID NO:
- 51, a CDR-H2 comprising the amino acid sequence set forth in SEQ ID NO:
- 52, and a CDR-H3 comprising the amino acid sequence set forth in SEQ ID NO:
- 53;
- and
- a light chain comprising a light chain variable (VL) domain, wherein the VL domain comprises a CDR-L1 comprising the amino acid sequence set forth in SEQ ID NO:
- 54, a CDR-L2 comprising the amino acid sequence set forth in SEQ ID NO:
- 55, and a CDR-L3 comprising the amino acid sequence set forth in SEQ ID NO:
- 56.
6 more elements
Dependencies are inferred from the claim text.