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US 11,634,498 B2Granted
Chimeric antigen receptors and uses thereof
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsScott A. Rivkees, Christopher Wendler, Lung-Ji Chang
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Abstract
Aspects of the disclosure relate to chimeric antigen receptors (CARs) comprising an antigen binding domain (e.g., anti-TSHR), transmembrane domain (e.g., CD28), and a cytoplasmic domain (e.g., CD27, CD-137, etc.) and a safety mechanism comprising an inducible apoptosis trigger. In some aspects, the disclosure relates to use of the CARs in T cells, compositions, kits and methods for the treatment of thyroid cancers.
Claims12
A chimeric antigen receptor (CAR) comprising:
- an antigen binding domain a single-chain variable fragment (scFv) specific for thyroid specific hormone receptor (TSHR), wherein the scFv comprises the following complementarity determining regions (CDRs):
- NYWMN (SEQ ID NO:
- 11), RIDPSDSETHYNQNFKD (SEQ ID NO:
- 12), SGY, KSSQSLLDSDGKTYLN (SEQ ID NO:
- 14), LVSKVDS (SEQ ID NO:
- 15), and WQGTHSPLT (SEQ ID NO:
- 16);
- a transmembrane domain;
- a cytoplasmic domain containing one or more of a CD28 signaling domain, a CD 137 intracellular domain, a CD27 domain, a CD3zeta signal transduction domain;
- and a cytoplasmic domain that contains an inducible trigger of apoptosis.
7 more elements
Dependencies are inferred from the claim text.