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US 11,634,496 B2Granted
C-MET agonistic antibody and use thereof
AssigneeTongji University Suzhou Institute Biomedical Research Center
InventorsJianmin Fang, Ming Jiang, Yanxin Yin, Jia Guo, Lihua Yu
Life of this patent
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Abstract
A method for treating or preventing vascular endothelial cell injured diseases, especially cerebral infarctions or myocardial infarctions, by administering a c-MET agonist antibody to a subject in need thereof, and specific c-MET agonist antibodies.
Claims6
An antibody or functional fragment thereof capable of binding to c-MET, comprising a heavy chain and a light chain, wherein:
- the heavy chain comprises a heavy chain variable region which comprises a CDR1 of SEQ ID NO:
- 9, a CDR2 of SEQ ID NO:
- 10, and a CDR3 of SEQ ID NO:
- 11, and
- the light chain comprises a light chain variable region which comprises a CDR1 of SEQ ID NO:
- 12, a CDR2 of SEQ ID NO:
- 13, and a CDR3 of SEQ ID NO:
- 14.
5 more elements
Dependencies are inferred from the claim text.