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US 11,634,494 B2Granted
Anti HLA-G specific antibodies
AssigneeInvectys
InventorsPierre Langlade Demoyen, Thierry Huet, Julien Caumartin, Maria Loustau, Maria Wehbe
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Abstract
The present invention relates to antibodies, or antigen-binding fragments thereof, directed against human leukocyte antigen-G (HLA-G) protein and raised against an immunogenic peptide derived from the α3 domain of HLA-G protein. The invention further relates to the immunogenic peptide, and methods for producing said anti-HLA-G specific antibodies.
Claims9
A pharmaceutical composition comprising an anti-human leukocyte antigen G (HLA-G) antibody or an antigen-binding fragment thereof, and a pharmaceutical carrier;
- wherein the antibody or antigen-binding fragment comprises:
- (a) a heavy chain variable region (VH) comprising a heavy chain complementarity determining region 1 (HC CDR1) of SEQ ID NO:
- 8, a heavy chain complementarity determining region 2 (HC CDR2) of SEQ ID NO:
- 10, and a heavy chain complementarity determining region 3 (HC CDR3) of SEQ ID NO:
- 12;
- and
- (b) a light chain variable region (VL) comprising a light chain complementarity determining region 1 (LC CDR1) of SEQ ID NO:
- 2, a light chain complementarity determining region 2 (LC CDR2) of sequence KVS and a light chain complementarity determining region 3 (LC CDR3) of SEQ ID NO:
- 5.
6 more elements
Dependencies are inferred from the claim text.