Anti-TREM2 antibodies and methods of use thereof
AssigneeAlector LLC
InventorsTina Schwabe, Eric Brown, Philip Kong, Ilaria Tassi, Seung-Joo Lee, Arnon Rosenthal, Robert Pejchal, Nels P. Nielson
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Abstract
The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.
Claims32
A method of treating an individual having Alzheimer's disease, comprising administering to an individual in need thereof a therapeutically effective amount of an antibody that binds to a human TREM2 protein, wherein the antibody comprises a heavy chain variable region comprising an HVR-H1, HVR-H2, and HVR-H3 and a light chain variable region comprising an HVR-L1, HVR-L2, and HVR-L3, wherein the HVR-H1 comprises the sequence of SEQ ID NO:
- 132, the HVR-H2 comprises the sequence of SEQ ID NO:
- 135, the HVR-H3 comprises the sequence of SEQ ID NO:
- 126, the HVR-L1 comprises the sequence of SEQ ID NO:
- 144, the HVR-L2 comprises the sequence of SEQ ID NO:
- 131, and the HVR-L3 comprises the sequence of SEQ ID NO:
- 129.
A method of treating an individual having Alzheimer's disease, comprising administering to an individual in need thereof a therapeutically effective amount of an antibody that binds to a human TREM2 protein, wherein the antibody comprises a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 59 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 112.
A method of treating an individual having Alzheimer's disease, comprising administering to an individual in need thereof a therapeutically effective amount of an antibody that binds to a human TREM2 protein, wherein the antibody comprises a heavy chain and a light chain, wherein:
- (a) the heavy chain comprises the amino acid sequence of SEQ ID NO:
- 198, and the light chain comprises the amino acid sequence of SEQ ID NO:
- 214;
- (b) the heavy chain comprises the amino acid sequence of SEQ ID NO:
- 199, and the light chain comprises the amino acid sequence of SEQ ID NO:
- 214;
- (c) the heavy chain comprises the amino acid sequence of SEQ ID NO:
- 200, and the light chain comprises the amino acid sequence of SEQ ID NO:
- 214;
- or
- (d) the heavy chain comprises the amino acid sequence of SEQ ID NO:
- 201, and the light chain comprises the amino acid sequence of SEQ ID NO:
- 214.
Dependencies are inferred from the claim text.