Diagnostic method
OwnerUlrich Birsner, Hassan Jumaa +2inventors
InventorsUlrich Birsner, Hassan Jumaa, Holger Klapproth, Marc A. Kessemeier
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Abstract
The present invention relates to the field of production, identification and selection of biological binding molecules such as antibodies or fragments thereof, as well as to diagnostic procedures using them in the diagnosis of cancers, in particular malignant B-cell neoplasia. The binding molecules are able to selectively bind to autonomously active or autonomously activated B-cell receptors, the autonomously active or autonomously activated B-cell receptors being characterized by the presence of structural domains to which the binding molecule selectively binds and which are responsible for the autonomously active or autonomously activated state of the B-cell receptors.
Claims8
A diagnostic method for detecting autonomously active or autonomously activated B-cell receptors in a sample comprising adding to the sample an isolated antibody or functional fragment thereof, wherein a partial sequence of the heavy chain of the isolated antibody or functional fragment thereof corresponding to CDR1 is SEQ ID NO:
- 11, corresponding to CDR2 is SEQ ID NO:
- 12, and corresponding to CDR3 is SEQ ID NO:
- 13, and a partial sequence of the light chain of the isolated antibody or functional fragment thereof corresponding to CDR1 is SEQ ID NO:
- 14, corresponding to CDR2 is SEQ ID NO:
- 15, and corresponding to CDR3 is SEQ ID NO:
- 16, wherein said isolated antibody or functional fragment thereof selectively binds to autonomously active or autonomously activated B-cell receptors, and wherein the autonomously active or autonomously activated B-cell receptors are characterized by the presence of structural domains or epitopes to which the isolated antibody or functional fragment thereof selectively binds and which are causative for the autonomously active or autonomously activated state of the B-cell receptors.
Dependencies are inferred from the claim text.