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US 11,634,485 B2Granted
Therapeutic antibody formulation
AssigneeEli Lilly and Company
InventorsVincent John Corvari, Karthik Pisupati
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Abstract
Stable aqueous pharmaceutical formulations for therapeutic antibodies and methods of using such stable aqueous pharmaceutical formulations.
Claims9
A bufferless aqueous pharmaceutical formulation comprising:
- (i) an anti-IL-17A antibody at a concentration of 80 mg/mL+/−10%;
- (ii) sucrose in a concentration of 234 mM+/−10%;
- and
- (iv) a surfactant in a concentration of between 0.005% w/v+/−10% to 0.05% w/v+/−10%,
- wherein, the pharmaceutical formulation is an aqueous solution at a pH between 5.2 to 6.5 and the anti-IL17A antibody comprises a light chain variable region (LCVR) and a heavy chain variable region (HCVR), wherein the LCVR comprises complementarity determining regions (CDRs) LCDR1, LCDR2, and LCDR3 and the HCVR comprises CDRs HCDR1, HCDR2, and HCDR3, wherein:
- LCDR1 comprises the amino acid sequence of SEQ ID NO. 1,
- LCDR2 comprises the amino acid sequence of SEQ ID NO. 2,
- LCDR3 comprises the amino acid sequence of SEQ ID NO. 3,
- HCDR1 comprises the amino acid sequence of SEQ ID NO. 4,
- HCDR2 comprises the amino acid sequence of SEQ ID NO. 5, and
- HCDR3 comprises the amino acid sequence of SEQ ID NO. 6.
8 more elements
Dependencies are inferred from the claim text.