Immunoassay for collagen type VI
AssigneeNordic Bioscience A/S
InventorsAnders Nedergaard, Jannie Marie Sand, Shu Sun, Diana Julie Oersnes-Leeming, Kim Henriksen
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Abstract
The present invention provides an immunological binding partner reactive with a C-terminal epitope of the C5 domain of the α3 chain of collagen Type 6, and a method of immunoassay using the immunological binding partner for detecting and quantifying the C-terminal epitope. The invention also provides a method of investigating the rate of formation of extracellular matrix and a method for identifying a subject suitable for treatment with an insulin sensitizer.
Claims11
An isolated monoclonal antibody that specifically binds a C-terminal epitope of the C5 domain of the a3 chain of collagen Type 6, wherein the antibody comprises
- (a) a variable heavy chain region comprising CDRH1 comprising the amino acid sequence of SEQ ID NO.:
- 6, CDRH2 comprising the amino acid sequence of SEQ ID NO.:
- 7, and CDRH3 comprising the amino acid sequence of SEQ ID NO.:
- 8;
- and
- (b) a variable light chain region comprising CDRL1 comprising the amino acid sequence of SEQ ID NO.:
- 10, CDRL2 comprising the amino acid sequence of SEQ ID NO.:
- 11, and CDRL3 comprising the amino acid sequence of SEQ ID NO.:
- 12,
- wherein the antibody specifically binds the amino acid sequence consisting of SEQ ID NO:1.
Dependencies are inferred from the claim text.