Back to results
US 11,634,471 B2Granted
Transduced T cells expressing human SSTR2 and application thereof
AssigneeCornell University
InventorMoonsoo Jin
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeCornell University
InventorMoonsoo Jin
Estimating the term…
The present invention is directed to transduced T cells expressing at least 100,000 molecules of human somatostatin receptor 2 (SSTR2), which improves PET/CT imaging sensitivity. The present invention is also directed to transduced T cells expressing SSTR2 and chimeric antigen receptor (CAR). In one embodiment, the CAR is specific to human ICAM-1 and the CAR comprises a binding domain that is scFv of anti-human ICAM-1, or an I domain of the αL subunit of human lymphocyte function-associated antigen-1. In another embodiment, the CAR is specific to human CD19, and the CAR comprises a binding domain that is scFv of anti-human CD19. The present invention is further directed to using the above transduced T cells for monitoring T cell distribution in a patient by PET/CT imaging and/or treating cancer.
Transduced T cells that express SSTR2 and a chimeric antigen receptor (CAR) specific to ICAM-1, wherein the CAR comprises a binding domain to human ICAM-1, wherein the binding domain is an I domain of the α L subunit human lymphocyte function-associated antigen-1, wherein the I domain is a mutant of the wild type I domain comprising the sequence of amino acids 130-310 of SE ID NO:1, and wherein the mutation is F292A, F292S, L289G, F292G, or F265S.
Dependencies are inferred from the claim text.